Positive impact of autophagy in human breast cancer cells on local immunosurveillance

Sylvain Ladoire; David Enot; Laura Senovilla; Marie Chaix; Laurence Zitvogel; Guido Kroemer

doi:10.1080/2162402X.2016.1174801

Positive impact of autophagy in human breast cancer cells on local immunosurveillance

Sylvain Ladoire, David Enot, Laura Senovilla, Marie Chaix, Laurence Zitvogel, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B⁺ puncta within malignant cells positively correlate with the intratumoral abundance of CD8⁺ cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3⁺ regulatory T cells and CD68⁺ tumor-associated macrophages, resulting in an improvement of CD8⁺/FOXP⁺ or CD8⁺/CD68⁺ ratios.

Original language	English
Article number	e1174801
Journal	OncoImmunology
Volume	5
Issue number	6
DOIs	https://doi.org/10.1080/2162402X.2016.1174801
Publication status	Published - 2 Jun 2016

Keywords

Autophagy
LC3
Treg cells
breast cancer
lymphocytes
macrophages

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10.1080/2162402X.2016.1174801

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title = "Positive impact of autophagy in human breast cancer cells on local immunosurveillance",

abstract = "In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B+ puncta within malignant cells positively correlate with the intratumoral abundance of CD8+ cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3+ regulatory T cells and CD68+ tumor-associated macrophages, resulting in an improvement of CD8+/FOXP+ or CD8+/CD68+ ratios.",

keywords = "Autophagy, LC3, Treg cells, breast cancer, lymphocytes, macrophages",

author = "Sylvain Ladoire and David Enot and Laura Senovilla and Marie Chaix and Laurence Zitvogel and Guido Kroemer",

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year = "2016",

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doi = "10.1080/2162402X.2016.1174801",

language = "English",

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T1 - Positive impact of autophagy in human breast cancer cells on local immunosurveillance

AU - Ladoire, Sylvain

AU - Enot, David

AU - Senovilla, Laura

AU - Chaix, Marie

AU - Zitvogel, Laurence

AU - Kroemer, Guido

PY - 2016/6/2

Y1 - 2016/6/2

N2 - In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B+ puncta within malignant cells positively correlate with the intratumoral abundance of CD8+ cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3+ regulatory T cells and CD68+ tumor-associated macrophages, resulting in an improvement of CD8+/FOXP+ or CD8+/CD68+ ratios.

AB - In human breast cancer cells, the presence of cytoplasmic dots positive for microtubule-associated proteins 1A/1B light chain 3B (LC3B) indicates enhanced autophagic flux and favorable prognosis. LC3B+ puncta within malignant cells positively correlate with the intratumoral abundance of CD8+ cytotoxic T lymphocytes, yet negatively correlate with the frequency of local FOXP3+ regulatory T cells and CD68+ tumor-associated macrophages, resulting in an improvement of CD8+/FOXP+ or CD8+/CD68+ ratios.

KW - Autophagy

KW - LC3

KW - Treg cells

KW - breast cancer

KW - lymphocytes

KW - macrophages

UR - http://www.scopus.com/inward/record.url?scp=84976321223&partnerID=8YFLogxK

U2 - 10.1080/2162402X.2016.1174801

DO - 10.1080/2162402X.2016.1174801

M3 - Article

AN - SCOPUS:84976321223

SN - 2162-4011

VL - 5

JO - OncoImmunology

JF - OncoImmunology

IS - 6

M1 - e1174801

ER -

Positive impact of autophagy in human breast cancer cells on local immunosurveillance

Abstract

Keywords

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