Practical considerations in the management of hand-foot skin reaction caused by multikinase inhibitors

Laura S. Wood; Harvey Lemont; Aminah Jatoi; Mario E. Lacouture; Caroline Robert; Karen Keating; Roger Anderson

doi:10.1016/S1548-5315(11)70385-0

Practical considerations in the management of hand-foot skin reaction caused by multikinase inhibitors

Laura S. Wood, Harvey Lemont, Aminah Jatoi, Mario E. Lacouture, Caroline Robert, Karen Keating, Roger Anderson

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22 Citations (Scopus)

Abstract

Multikinase inhibitors (MKIs, eg, sorafenib and sunitinib) are oral anticancer agents associated with handfoot skin reaction (HFSR), a cutaneous adverse event affecting 20%-40% of patients treated with these drugs. Although usually mild, symptoms of HFSR can evolve into a painful condition, resulting in a shortened duration or intensity of cancer treatment. An international, interdisciplinary panel of experts recently provided the first consensus recommendations for the management of MKI-associated HFSR.

Original language	English
Pages (from-to)	23-29
Number of pages	7
Journal	Community Oncology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/S1548-5315(11)70385-0
Publication status	Published - 1 Jan 2010

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AU - Keating, Karen

AU - Anderson, Roger

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AB - Multikinase inhibitors (MKIs, eg, sorafenib and sunitinib) are oral anticancer agents associated with handfoot skin reaction (HFSR), a cutaneous adverse event affecting 20%-40% of patients treated with these drugs. Although usually mild, symptoms of HFSR can evolve into a painful condition, resulting in a shortened duration or intensity of cancer treatment. An international, interdisciplinary panel of experts recently provided the first consensus recommendations for the management of MKI-associated HFSR.

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Practical considerations in the management of hand-foot skin reaction caused by multikinase inhibitors

Abstract

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