Preconditioning with immunogenic cell death-inducing treatments for subsequent immunotherapy

Hui Pan, Peng Liu, Guido Kroemer, Oliver Kepp

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    4 Citations (Scopus)

    Abstract

    Since the dawn of anticancer immunotherapy, the clinical use of immune checkpoint inhibitors (ICI) has increased exponentially. Monoclonal antibodies targeting CTLA-4 and the PD-1/PD-L1 interaction were first introduced for the treatment of patients with unresectable melanoma. In melanoma, ICI lead to durable regression in a significant number of patients and have thus been clinically approved as a first-line treatment of advanced disease. Over the past years an increasing number of regulatory approvals have been granted for the use of ICI in patients affected by a large range of distinct carcinomas. In retrospect surprisingly, it has been discovered that particularly successful chemotherapeutic treatments are able to trigger anticancer immune responses because they induce immunogenic cell death (ICD), hence killing cancer cells in a way that they elicit an immune response against tumor-associated antigens. Logically, preclinical studies as well as clinical trials are currently exploring the possibility to combine ICD inducers with ICI to obtain optimal therapeutic effects. Here, we provide a broad overview of current strategies for the implementation of combinatorial approaches involving ICD induction followed by ICI in anticancer therapy.

    Original languageEnglish
    Title of host publicationImmune Checkpoint Biology in Health and Disease
    PublisherElsevier Inc.
    Pages279-294
    Number of pages16
    DOIs
    Publication statusPublished - 1 Jan 2024

    Publication series

    NameInternational Review of Cell and Molecular Biology
    Volume382
    ISSN (Print)1937-6448

    Keywords

    • Adjuvanticity
    • CTLA-4
    • Cancer
    • Immunotherapy
    • PD-1
    • PD-L1

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