Pro-ferroptotic fatty acid metabolism renders cancer cells immunogenic

Oliver Kepp, Guido Kroemer

    Research output: Contribution to journalShort surveypeer-review

    8 Citations (Scopus)

    Abstract

    Tumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFNγ produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis, correlating with increased immunosurveillance and response to checkpoint blockade.

    Original languageEnglish
    Pages (from-to)785-787
    Number of pages3
    JournalTrends in Cancer
    Volume8
    Issue number10
    DOIs
    Publication statusPublished - 1 Oct 2022

    Keywords

    • PARP
    • immunogenic cell death
    • immunotherapy

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