Abstract
Tumor cell-intrinsic metabolic features can affect the cancer-immunity dialogue. In a recent paper published in Cancer Cell, Liao et al. demonstrate that IFNγ produced by T cells, together with arachidonic acid, can induce acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated ferroptosis, correlating with increased immunosurveillance and response to checkpoint blockade.
Original language | English |
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Pages (from-to) | 785-787 |
Number of pages | 3 |
Journal | Trends in Cancer |
Volume | 8 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2022 |
Keywords
- PARP
- immunogenic cell death
- immunotherapy