Problématique des marqueurs histopronostiques dans les tumeurs neuroendocrines digestives

J. Y. Scoazec

doi:10.1007/s10269-013-2332-4

Problématique des marqueurs histopronostiques dans les tumeurs neuroendocrines digestives

Translated title of the contribution: Histoprognostic factors in digestive neuroendocrine tumors

J. Y. Scoazec

Research output: Contribution to journal › Article › peer-review

Abstract

The evaluation of prognosis is essential for the management of a patient with a neuroendocrine tumor, especially digestive, in which the risk of malignancy is significant. Three validated histoprognostic factors are available from the pathological examination: morphological differentiation status, histological grade, and pTNM stage. Numerous prognostic biomarkers have been proposed in the literature but none has been transposed to clinical practice. In the sameway, among the candidate predictive biomarkers, only MGMT is an emerging biomarker, which may be useful for the prediction of the response to temozolomide.

Translated title of the contribution	Histoprognostic factors in digestive neuroendocrine tumors
Original language	French
Pages (from-to)	510-514
Number of pages	5
Journal	Oncologie
Volume	15
Issue number	10-11
DOIs	https://doi.org/10.1007/s10269-013-2332-4
Publication status	Published - 1 Oct 2013
Externally published	Yes

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abstract = "The evaluation of prognosis is essential for the management of a patient with a neuroendocrine tumor, especially digestive, in which the risk of malignancy is significant. Three validated histoprognostic factors are available from the pathological examination: morphological differentiation status, histological grade, and pTNM stage. Numerous prognostic biomarkers have been proposed in the literature but none has been transposed to clinical practice. In the sameway, among the candidate predictive biomarkers, only MGMT is an emerging biomarker, which may be useful for the prediction of the response to temozolomide.",

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N2 - The evaluation of prognosis is essential for the management of a patient with a neuroendocrine tumor, especially digestive, in which the risk of malignancy is significant. Three validated histoprognostic factors are available from the pathological examination: morphological differentiation status, histological grade, and pTNM stage. Numerous prognostic biomarkers have been proposed in the literature but none has been transposed to clinical practice. In the sameway, among the candidate predictive biomarkers, only MGMT is an emerging biomarker, which may be useful for the prediction of the response to temozolomide.

AB - The evaluation of prognosis is essential for the management of a patient with a neuroendocrine tumor, especially digestive, in which the risk of malignancy is significant. Three validated histoprognostic factors are available from the pathological examination: morphological differentiation status, histological grade, and pTNM stage. Numerous prognostic biomarkers have been proposed in the literature but none has been transposed to clinical practice. In the sameway, among the candidate predictive biomarkers, only MGMT is an emerging biomarker, which may be useful for the prediction of the response to temozolomide.

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KW - Proliferation indexes

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Problématique des marqueurs histopronostiques dans les tumeurs neuroendocrines digestives

Abstract

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