Prognostic factors and outcome of undifferentiated endometrial sarcoma treated by multimodal therapy

Gabriel G. Malouf, Catherine Lhommé, Pierre Duvillard, Philippe Morice, Christine Haie-Meder, Patricia Pautier

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    35 Citations (Scopus)

    Abstract

    Objective To describe the natural history, prognostic factors, and optimal treatment modalities of undifferentiated endometrial sarcoma (UES). Methods A retrospective review was conducted of 30 patients with UES treated at Institut Gustave-Roussy, France, between January 1978 and December 2008. Clinical and pathologic variables, treatment modalities, and outcomes were assessed. Results Disease was advanced in most cases: FIGO stage III-IV in 70% of patients. Overall, 29 patients (96.7%) underwent hysterectomy as part of the initial surgical treatment; however, only 18 (60.0%) attained complete macroscopic resection. The incidence of pelvic and/or para-aortic lymph-node involvement at primary surgery or first recurrence was 44.4%. Median postoperative follow-up was 5 years; progression-free survival (PFS) and overall survival (OS) were 9.7 and 23 months, respectively. No differences in OS and PFS were observed by staging subgroup (FIGO vs the American Joint Committee on Cancer). Only postoperative pelvic radiotherapy with or without brachytherapy correlated with improved PFS (19.1 vs 6.5 months; P = 0.04) and OS (54.5 vs 16.7 months; P = 0.01) in a univariate analysis. Conclusion Neither staging system was optimal for risk stratification. Multimodal therapy was recommended after surgery.

    Original languageEnglish
    Pages (from-to)57-61
    Number of pages5
    JournalInternational Journal of Gynecology and Obstetrics
    Volume122
    Issue number1
    DOIs
    Publication statusPublished - 1 Jan 2013

    Keywords

    • Multimodal therapy
    • Outcome
    • Recurrence
    • Staging
    • Survival
    • Undifferentiated endometrial sarcoma

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