Prognostic value and therapeutic implications of nodal involvement in head and neck mucosal melanoma

Antoine Moya-Plana; David Mangin; Pierre Blanchard; Rais Obongo; Odile Casiraghi; François Bidault; Stéphane Temam; Caroline Robert; Philippe Gorphe

doi:10.1002/hed.26694

Prognostic value and therapeutic implications of nodal involvement in head and neck mucosal melanoma

Antoine Moya-Plana, David Mangin, Pierre Blanchard, Rais Obongo, Odile Casiraghi, François Bidault, Stéphane Temam, Caroline Robert, Philippe Gorphe

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Background: The prognostic significance of nodal involvement is not well established in head and neck mucosal melanoma (HNMM). Methods: A retrospective, monocentric study was performed on 96 patients with HNMM treated between 2000 and 2017. Results: At diagnosis, seventeen patients (17.8%) were cN1, with a higher risk for HNMM arising from the oral cavity (p = 0.01). cN status had no prognostic value in patients with nonmetastatic resectable HNMM. No occult nodal metastasis was observed in the cN0 patients after a nodal dissection (ND). The nodal recurrence rate was similar in the cN1 and the cN0 patients. No isolated nodal recurrences were noted. Among the patients who underwent a ND, no benefit of this procedure was noted. Conclusions: cN1 status is not a prognostic factor in patients with resectable HNMM. Elective ND should not be systematically performed in cN0 HNMM.

Original language	English
Pages (from-to)	2325-2331
Number of pages	7
Journal	Head and Neck
Volume	43
Issue number	8
DOIs	https://doi.org/10.1002/hed.26694
Publication status	Published - 1 Aug 2021

Keywords

head and neck
mucosal melanoma
nodal involvement
prognosis
regional

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10.1002/hed.26694

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title = "Prognostic value and therapeutic implications of nodal involvement in head and neck mucosal melanoma",

abstract = "Background: The prognostic significance of nodal involvement is not well established in head and neck mucosal melanoma (HNMM). Methods: A retrospective, monocentric study was performed on 96 patients with HNMM treated between 2000 and 2017. Results: At diagnosis, seventeen patients (17.8%) were cN1, with a higher risk for HNMM arising from the oral cavity (p = 0.01). cN status had no prognostic value in patients with nonmetastatic resectable HNMM. No occult nodal metastasis was observed in the cN0 patients after a nodal dissection (ND). The nodal recurrence rate was similar in the cN1 and the cN0 patients. No isolated nodal recurrences were noted. Among the patients who underwent a ND, no benefit of this procedure was noted. Conclusions: cN1 status is not a prognostic factor in patients with resectable HNMM. Elective ND should not be systematically performed in cN0 HNMM.",

keywords = "head and neck, mucosal melanoma, nodal involvement, prognosis, regional",

author = "Antoine Moya-Plana and David Mangin and Pierre Blanchard and Rais Obongo and Odile Casiraghi and Fran{\c c}ois Bidault and St{\'e}phane Temam and Caroline Robert and Philippe Gorphe",

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year = "2021",

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doi = "10.1002/hed.26694",

language = "English",

volume = "43",

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T1 - Prognostic value and therapeutic implications of nodal involvement in head and neck mucosal melanoma

AU - Moya-Plana, Antoine

AU - Mangin, David

AU - Blanchard, Pierre

AU - Obongo, Rais

AU - Casiraghi, Odile

AU - Bidault, François

AU - Temam, Stéphane

AU - Robert, Caroline

AU - Gorphe, Philippe

PY - 2021/8/1

Y1 - 2021/8/1

N2 - Background: The prognostic significance of nodal involvement is not well established in head and neck mucosal melanoma (HNMM). Methods: A retrospective, monocentric study was performed on 96 patients with HNMM treated between 2000 and 2017. Results: At diagnosis, seventeen patients (17.8%) were cN1, with a higher risk for HNMM arising from the oral cavity (p = 0.01). cN status had no prognostic value in patients with nonmetastatic resectable HNMM. No occult nodal metastasis was observed in the cN0 patients after a nodal dissection (ND). The nodal recurrence rate was similar in the cN1 and the cN0 patients. No isolated nodal recurrences were noted. Among the patients who underwent a ND, no benefit of this procedure was noted. Conclusions: cN1 status is not a prognostic factor in patients with resectable HNMM. Elective ND should not be systematically performed in cN0 HNMM.

AB - Background: The prognostic significance of nodal involvement is not well established in head and neck mucosal melanoma (HNMM). Methods: A retrospective, monocentric study was performed on 96 patients with HNMM treated between 2000 and 2017. Results: At diagnosis, seventeen patients (17.8%) were cN1, with a higher risk for HNMM arising from the oral cavity (p = 0.01). cN status had no prognostic value in patients with nonmetastatic resectable HNMM. No occult nodal metastasis was observed in the cN0 patients after a nodal dissection (ND). The nodal recurrence rate was similar in the cN1 and the cN0 patients. No isolated nodal recurrences were noted. Among the patients who underwent a ND, no benefit of this procedure was noted. Conclusions: cN1 status is not a prognostic factor in patients with resectable HNMM. Elective ND should not be systematically performed in cN0 HNMM.

KW - head and neck

KW - mucosal melanoma

KW - nodal involvement

KW - prognosis

KW - regional

UR - http://www.scopus.com/inward/record.url?scp=85103370336&partnerID=8YFLogxK

U2 - 10.1002/hed.26694

DO - 10.1002/hed.26694

M3 - Article

C2 - 33783056

AN - SCOPUS:85103370336

SN - 1043-3074

VL - 43

SP - 2325

EP - 2331

JO - Head and Neck

JF - Head and Neck

IS - 8

ER -

Prognostic value and therapeutic implications of nodal involvement in head and neck mucosal melanoma

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Keywords

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