Propriétés et rôles biologiques des protéines TET au cours du développement et de l'hématopoïèse

Emna Mahfoudhi; Lise Secardin; Laurianne Scourzic; Olivier Bernard; William Vainchenker; Isabelle Plo

doi:10.1051/medsci/20153103012

Propriétés et rôles biologiques des protéines TET au cours du développement et de l'hématopoïèse

Translated title of the contribution: Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis

Emna Mahfoudhi, Lise Secardin, Laurianne Scourzic, Olivier Bernard, William Vainchenker, Isabelle Plo

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.

Translated title of the contribution	Properties and biological roles of TET proteins during embryogenesis and in hematopoiesis
Original language	French
Pages (from-to)	268-274
Number of pages	7
Journal	Medecine/Sciences
Volume	31
Issue number	3
DOIs	https://doi.org/10.1051/medsci/20153103012
Publication status	Published - 1 Mar 2015

Access to Document

10.1051/medsci/20153103012

Cite this

@article{dd7c8350a1d147219328934773df9aba,

title = "Propri{\'e}t{\'e}s et r{\^o}les biologiques des prot{\'e}ines TET au cours du d{\'e}veloppement et de l'h{\'e}matopo{\"i}{\`e}se",

abstract = "DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.",

author = "Emna Mahfoudhi and Lise Secardin and Laurianne Scourzic and Olivier Bernard and William Vainchenker and Isabelle Plo",

note = "Publisher Copyright: {\textcopyright} 2015 m{\'e}decine/sciences - Inserm.",

year = "2015",

month = mar,

day = "1",

doi = "10.1051/medsci/20153103012",

language = "Fran{\c c}ais",

volume = "31",

pages = "268--274",

journal = "Medecine/Sciences",

issn = "0767-0974",

number = "3",

}

TY - JOUR

T1 - Propriétés et rôles biologiques des protéines TET au cours du développement et de l'hématopoïèse

AU - Mahfoudhi, Emna

AU - Secardin, Lise

AU - Scourzic, Laurianne

AU - Bernard, Olivier

AU - Vainchenker, William

AU - Plo, Isabelle

PY - 2015/3/1

Y1 - 2015/3/1

N2 - DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.

AB - DNA methylation is associated with a large number of biological processes and mainly concerns the cytosine methylation at position 5 (5-mC). An active demethylation mechanism was highlighted in 2009 following the discovery that TET proteins were enzymes implicated in the hydroxylation of 5-mC to 5-hydroxymethylcytosine. Simultaneously, other studies showed frequent acquired TET2 mutations in hematological malignancies and have depicted their role in their pathogenesis. An entire field of research has developed rapidly showing that these proteins are involved in many biological processes.

UR - http://www.scopus.com/inward/record.url?scp=84927731771&partnerID=8YFLogxK

U2 - 10.1051/medsci/20153103012

DO - 10.1051/medsci/20153103012

M3 - Article

C2 - 25855280

AN - SCOPUS:84927731771

SN - 0767-0974

VL - 31

SP - 268

EP - 274

JO - Medecine/Sciences

JF - Medecine/Sciences

IS - 3

ER -

Propriétés et rôles biologiques des protéines TET au cours du développement et de l'hématopoïèse

Abstract

Access to Document

Other files and links

Cite this