Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

Adrien Joseph; Juncheng Pan; Judith Michels; Guido Kroemer; Maria Castedo

doi:10.1080/2162402X.2021.1950954

Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

Adrien Joseph, Juncheng Pan, Judith Michels, Guido Kroemer, Maria Castedo

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.

Original language	English
Article number	1950954
Journal	OncoImmunology
Volume	10
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2021.1950954
Publication status	Published - 1 Jan 2021

Keywords

CD8+ T cells
Tumor microenvironment
cervical cancer
dendritic cells
immune escape
immunotherapy
metabolism
non-small cell lung cancer
survival
vitamin B

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10.1080/2162402X.2021.1950954

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title = "Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers",

abstract = "Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.",

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AU - Kroemer, Guido

AU - Castedo, Maria

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AB - Malignant cells adapt to the hostile tumor microenvironment by escaping from, or actively suppressing, anticancer immune responses. In the past, we reported that reduced synthesis of active vitamin B6 (due to downregulation of pyridoxal kinase) or overactivation of poly(ADP-ribose) polymerase confers resistance to chemotherapy with cisplatin. Recently, we found that these prognostically adverse alterations in oncometabolism also correlate with the rarefaction of immune effectors in the tumor bed.

KW - CD8+ T cells

KW - Tumor microenvironment

KW - cervical cancer

KW - dendritic cells

KW - immune escape

KW - immunotherapy

KW - metabolism

KW - non-small cell lung cancer

KW - survival

KW - vitamin B

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ER -

Pyridoxal kinase and poly(ADP-ribose) affect the immune microenvironment of locally advanced cancers

Abstract

Keywords

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