TY - JOUR
T1 - Quality-of-life assessment in French patients with metastatic melanoma in real life
AU - Kandel, Marguerite
AU - Dalle, Stéphane
AU - Bardet, Aurélie
AU - Allayous, Clara
AU - Mortier, Laurent
AU - Dutriaux, Caroline
AU - Guillot, Bernard
AU - Leccia, Marie Thérèse
AU - Dalac, Sophie
AU - Legoupil, Delphine
AU - Saiag, Philippe
AU - Montaudie, Henri
AU - Arnault, Jean Philippe
AU - Brunet-Possenti, Florence
AU - Grob, Jean Jacques
AU - DeQuatrebarbes, Julie
AU - Beylot-Barry, Marie
AU - Lesimple, Thierry
AU - Aubin, François
AU - Maubec, Eve
AU - Granel-Brocard, Florence
AU - Stoebner, Pierre Emmanuel
AU - Dupuy, Alain
AU - Dreno, Brigitte
AU - Michiels, Stefan
AU - Lebbe, Céleste
AU - Borget, Isabelle
N1 - Publisher Copyright:
© 2019 American Cancer Society
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Background: Significant progress was recently observed in the treatment of metastatic melanoma (MM). With >50% of patients now reaching a second line of treatment and a significant improvement in the survival rate, an assessment of quality of life (QoL) during the whole course of the disease becomes necessary. The objective of this study was to describe the QoL of patients with MM in France, from their diagnosis of advanced disease to their death, in real life. Methods: QoL data were collected through MelBase, a prospective, French, multicentric cohort dedicated to the follow-up of adults with MM. QoL was assessed using the EuroQoL-5D questionnaire and the Functional Assessment of Cancer Treatment (FACT)-Melanoma questionnaire at the time of study inclusion, every 3 months, and at the time of each treatment change until death. To assess longitudinal changes from baseline to death, mixed-effect models for repeated-measures analyses were used to control for baseline covariates. Results: QoL was assessed in 1435 patients who were included in the study between 2013 and 2018. The median follow-up was 9.4 months, and 47% of patients died during follow-up. During first-line treatment, the model-based, mean utility score was 0.830 (95% CI, 0.818-0.843), the mean FACT-General score was 77.22 (95% CI, 76.23-78.22), and the mean FACT-Melanoma score was 129.46 (95% CI, 128.02-130.90). At the time of a change in treatment line, there was a decrease of −0.027 (95% CI, −0.03, −0.02) in the utility score, −1.82 (95% CI, −1.88, −1.76) in the FACT-General score, and −2.98 (95% CI, −3.05, −2.91) in the FACT-Melanoma score compared with first-line treatment. Conclusions: In the MelBase cohort, the QoL among patients with MM seems to be fairly stable over the whole disease course, although a small but significant decrease at time therapy is changed is observed.
AB - Background: Significant progress was recently observed in the treatment of metastatic melanoma (MM). With >50% of patients now reaching a second line of treatment and a significant improvement in the survival rate, an assessment of quality of life (QoL) during the whole course of the disease becomes necessary. The objective of this study was to describe the QoL of patients with MM in France, from their diagnosis of advanced disease to their death, in real life. Methods: QoL data were collected through MelBase, a prospective, French, multicentric cohort dedicated to the follow-up of adults with MM. QoL was assessed using the EuroQoL-5D questionnaire and the Functional Assessment of Cancer Treatment (FACT)-Melanoma questionnaire at the time of study inclusion, every 3 months, and at the time of each treatment change until death. To assess longitudinal changes from baseline to death, mixed-effect models for repeated-measures analyses were used to control for baseline covariates. Results: QoL was assessed in 1435 patients who were included in the study between 2013 and 2018. The median follow-up was 9.4 months, and 47% of patients died during follow-up. During first-line treatment, the model-based, mean utility score was 0.830 (95% CI, 0.818-0.843), the mean FACT-General score was 77.22 (95% CI, 76.23-78.22), and the mean FACT-Melanoma score was 129.46 (95% CI, 128.02-130.90). At the time of a change in treatment line, there was a decrease of −0.027 (95% CI, −0.03, −0.02) in the utility score, −1.82 (95% CI, −1.88, −1.76) in the FACT-General score, and −2.98 (95% CI, −3.05, −2.91) in the FACT-Melanoma score compared with first-line treatment. Conclusions: In the MelBase cohort, the QoL among patients with MM seems to be fairly stable over the whole disease course, although a small but significant decrease at time therapy is changed is observed.
KW - clinical practice
KW - immunotherapy
KW - metastatic melanoma
KW - quality of life
KW - real-life
KW - targeted therapy
UR - http://www.scopus.com/inward/record.url?scp=85074555972&partnerID=8YFLogxK
U2 - 10.1002/cncr.32554
DO - 10.1002/cncr.32554
M3 - Article
C2 - 31639198
AN - SCOPUS:85074555972
SN - 0008-543X
VL - 126
SP - 611
EP - 618
JO - Cancer
JF - Cancer
IS - 3
ER -