Radiation-induced angiosarcoma of the breast

A 73-year-old woman with a past history of surgery and radiotherapy for a right breast cancer was presenting with a quickly growing skin mass on her right breast. Skin biopsy revealed radiation-induced angiosarcoma. MRI showed extensive breast involvement without apparent glandular abnormalities on mammography and ultrasound. Radiation-induced angiosarcomas of the breast are rare malignant tumors with a poor prognosis occurring several years after breast cancer treatment with radiotherapy. Skin abnormalities are always present and should suggest the diagnosis and lead to perform skin biopsy. The mammography can be normal or presents non-specific post-therapeutic changes. MRI is necessary to evaluate the extension of the lesions.