Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma

J. Grill; D. Couanet; C. Cappelli; J. L. Habrand; D. Rodriguez; C. Sainte-Rose; C. Kalifa

doi:10.1002/1531-8249(199903)45:3<393::AID-ANA17>3.0.CO;2-B

Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma

J. Grill, D. Couanet, C. Cappelli, J. L. Habrand, D. Rodriguez, C. Sainte-Rose, C. Kalifa

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207 Citations (Scopus)

Abstract

Occlusive vasculopathy is a potential complication of radiotherapy in children with optic pathway glioma. With a median follow-up of 7 years, 13 of 69 children in this study developed clinical and radiological signs of occlusive vasculopathy after radiotherapy within a median interval of 36 months. The major risk factor was neurofibromatosis type 1. Radiotherapy should no longer be the first treatment in these settings. When radiotherapy is unavoidable, regular screening for cerebral vasculopathy is mandatory, as preventive treatment is available.

Original language	English
Pages (from-to)	393-396
Number of pages	4
Journal	Annals of Neurology
Volume	45
Issue number	3
DOIs	https://doi.org/10.1002/1531-8249(199903)45:3<393::AID-ANA17>3.0.CO;2-B
Publication status	Published - 18 Mar 1999

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10.1002/1531-8249(199903)45:3<393::AID-ANA17>3.0.CO;2-B

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abstract = "Occlusive vasculopathy is a potential complication of radiotherapy in children with optic pathway glioma. With a median follow-up of 7 years, 13 of 69 children in this study developed clinical and radiological signs of occlusive vasculopathy after radiotherapy within a median interval of 36 months. The major risk factor was neurofibromatosis type 1. Radiotherapy should no longer be the first treatment in these settings. When radiotherapy is unavoidable, regular screening for cerebral vasculopathy is mandatory, as preventive treatment is available.",

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AU - Grill, J.

AU - Couanet, D.

AU - Cappelli, C.

AU - Habrand, J. L.

AU - Rodriguez, D.

AU - Sainte-Rose, C.

AU - Kalifa, C.

PY - 1999/3/18

Y1 - 1999/3/18

N2 - Occlusive vasculopathy is a potential complication of radiotherapy in children with optic pathway glioma. With a median follow-up of 7 years, 13 of 69 children in this study developed clinical and radiological signs of occlusive vasculopathy after radiotherapy within a median interval of 36 months. The major risk factor was neurofibromatosis type 1. Radiotherapy should no longer be the first treatment in these settings. When radiotherapy is unavoidable, regular screening for cerebral vasculopathy is mandatory, as preventive treatment is available.

AB - Occlusive vasculopathy is a potential complication of radiotherapy in children with optic pathway glioma. With a median follow-up of 7 years, 13 of 69 children in this study developed clinical and radiological signs of occlusive vasculopathy after radiotherapy within a median interval of 36 months. The major risk factor was neurofibromatosis type 1. Radiotherapy should no longer be the first treatment in these settings. When radiotherapy is unavoidable, regular screening for cerebral vasculopathy is mandatory, as preventive treatment is available.

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Radiation-induced cerebral vasculopathy in children with neurofibromatosis and optic pathway glioma

Abstract

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