Real-life experience of ceritinib in crizotinib-pretreated ALK⁺advanced nonsmall cell lung cancer patients

Here we report our experience of ceritinib in crizotinib-pretreated patients with anaplastic lymphoma kinase (ALK) positive (ALK⁺) non-small cell lung cancer (NSCLC) in a French temporary authorisation for use (TAU) study. The French TAU study included crizotinib-pretreated patients with advanced ALK⁺or ROS protooncogene 1 positive (ROS1⁺) tumours. Patients received oral ceritinib (750 mg·day⁻¹as a starting dose) and best tumour response (as evaluated by the investigator) and safety were reported every 3 months. A total of 242. TAUs were granted from March 12, 2013 to August 05, 2015. Of the 242 patients, 228 had ALK+ NSCLC and 13 had ROS1⁺NSCLC. The median age of ALK⁺patients (n=214) was 58.5 years, 51.9% were female, 70.8% had an Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0–1 and 50.0% had brain metastases. Of the 149 efficacy evaluable ALK⁺NSCLC patients, 5.4% had a complete response (CR), 47.0% had a partial response (PR) and 22.8% had stable disease (SD). At September 05, 2015, the median duration of ceritinib treatment (n=182) was 3.9 months but 5.5 months for patients (n=71) with a follow-up of ⩾12 months. Higher objective response rate (ORR) was observed for patients with ECOG PS 0 to 1 (55.0% versus 42.4%) and those receiving prior crizotinib for >5 months (51.6% versus 36.1%). Treatment-related adverse events (AEs) were reported in 118 of 208 patients (56.7%), the most common being diarrhoea (22.1%) and hepatic toxicity (19.7%). Ceritinib (750 mg·day⁻¹) demonstrated efficacy similar efficacy to ASCEND-1, ASCEND-2 and phase 3. ASCEND-5 trials with manageable safety in crizotinib-pretreated patients with ALK⁺NSCLC.