Regulated cell death and adaptive stress responses

Lorenzo Galluzzi, José Manuel Bravo-San Pedro, Oliver Kepp, Guido Kroemer

    Research output: Contribution to journalReview articlepeer-review

    138 Citations (Scopus)

    Abstract

    Eukaryotic cells react to potentially dangerous perturbations of the intracellular or extracellular microenvironment by activating rapid (transcription-independent) mechanisms that attempt to restore homeostasis. If such perturbations persist, cells may still try to cope with stress by activating delayed and robust (transcription-dependent) adaptive systems, or they may actively engage in cellular suicide. This regulated form of cell death can manifest with various morphological, biochemical and immunological correlates, and constitutes an ultimate attempt of stressed cells to maintain organismal homeostasis. Here, we dissect the general organization of adaptive cellular responses to stress, their intimate connection with regulated cell death, and how the latter operates for the preservation of organismal homeostasis.

    Original languageEnglish
    Pages (from-to)2405-2410
    Number of pages6
    JournalCellular and Molecular Life Sciences
    Volume73
    Issue number11-12
    DOIs
    Publication statusPublished - 1 Jun 2016

    Keywords

    • Apoptosis
    • Autophagy
    • Ferroptosis
    • Mitochondrial permeability transition
    • Necroptosis

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