TY - JOUR
T1 - Resectable extra-pleural and extra-meningeal solitary fibrous tumours
T2 - A multi-centre prognostic study
AU - Pasquali, S.
AU - Gronchi, A.
AU - Strauss, D.
AU - Bonvalot, S.
AU - Jeys, L.
AU - Stacchiotti, S.
AU - Hayes, A.
AU - Honore, C.
AU - Collini, P.
AU - Renne, S. L.
AU - Alexander, N.
AU - Grimer, R. J.
AU - Callegaro, D.
AU - Sumathi, V. P.
AU - Gourevitch, D.
AU - Desai, A.
N1 - Publisher Copyright:
© 2016
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Background Extra-pleural and extra-meningeal solitary fibrous tumour (SFT) is a rare sarcoma histotype curable with surgery in the majority of patients. The behaviour of these tumours ranges from indolent/very low grade to malignant/high grade but it is still not possible to accurately predict prognosis after surgery. We have investigated a multi-centre series to stratify the risk of recurrence to patients with SFTs. Methods We retrospectively analysed the data from 243 patients who underwent surgery (2002–2011) at four sarcoma referral centres. Results Upon univariate analysis, hypercellularity, atypia, necrosis, high mitotic rate (ie >4 mitoses/10 HPF) were associated with both disease-free and overall survival. Surgical margins were a significant prognostic factor for disease-free (P = 0.007) but not for overall survival. Unexpectedly, larger tumour size was associated with a better prognosis (P = 0.038) and fewer recurrences (P = 0.024). Upon multivariable analysis, high mitotic rate (hazard ratio, HR = 2.85, P = 0.002), cellular atypia (HR = 1.62, P = 0.015) and hypercellularity (HR = 1.82, P = 0.031) were significantly associated with recurrences. A SFT recurrence score has been provided to stratify risk of recurrence. Conclusion This study provides a prognostic model to stratify risk of recurrence in patients with resectable SFTs. This allows clinician to decide on an optimal follow-up strategy and to select patients that may benefit from adjuvant treatments.
AB - Background Extra-pleural and extra-meningeal solitary fibrous tumour (SFT) is a rare sarcoma histotype curable with surgery in the majority of patients. The behaviour of these tumours ranges from indolent/very low grade to malignant/high grade but it is still not possible to accurately predict prognosis after surgery. We have investigated a multi-centre series to stratify the risk of recurrence to patients with SFTs. Methods We retrospectively analysed the data from 243 patients who underwent surgery (2002–2011) at four sarcoma referral centres. Results Upon univariate analysis, hypercellularity, atypia, necrosis, high mitotic rate (ie >4 mitoses/10 HPF) were associated with both disease-free and overall survival. Surgical margins were a significant prognostic factor for disease-free (P = 0.007) but not for overall survival. Unexpectedly, larger tumour size was associated with a better prognosis (P = 0.038) and fewer recurrences (P = 0.024). Upon multivariable analysis, high mitotic rate (hazard ratio, HR = 2.85, P = 0.002), cellular atypia (HR = 1.62, P = 0.015) and hypercellularity (HR = 1.82, P = 0.031) were significantly associated with recurrences. A SFT recurrence score has been provided to stratify risk of recurrence. Conclusion This study provides a prognostic model to stratify risk of recurrence in patients with resectable SFTs. This allows clinician to decide on an optimal follow-up strategy and to select patients that may benefit from adjuvant treatments.
KW - Haemangiopericytoma
KW - Prognosis
KW - Sarcoma
KW - Solitary fibrous tumour
UR - http://www.scopus.com/inward/record.url?scp=84975748792&partnerID=8YFLogxK
U2 - 10.1016/j.ejso.2016.01.023
DO - 10.1016/j.ejso.2016.01.023
M3 - Article
C2 - 26924782
AN - SCOPUS:84975748792
SN - 0748-7983
VL - 42
SP - 1064
EP - 1070
JO - European Journal of Surgical Oncology
JF - European Journal of Surgical Oncology
IS - 7
ER -