Role of the permeability transition pore complex in lethal inter-organelle crosstalk

Ossama Sharaf El Dein, Cindy Gallerne, Aurelien Deniaud, Catherine Brenner, Christophe Lemaire

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

The endoplasmic reticulum (ER) function is critical for multiple cellular activities. Hence, impairment of the physiological function of the ER, such as accumulation of unfolded proteins or disturbance of lumenal calcium homeostasis, leads to an evolutionarily conserved adaptive response known as the ER stress response. Activation of this self-protective pathway gives the cell a chance to restore normal ER function. In the case of prolonged or severe stress conditions, or if the ER dysfunctions cannot be compensated, apoptosis is ultimately activated to eliminate stressed cells. Although the molecular mechanisms involved in ER stress-mediated apoptosis are poorly understood, it is known that ER and mitochondria can cooperate to induce cell death. In this review, we discuss the commitment and development of the lethal crosstalk between ER and mitochondria and focus on the role of the mitochondrial permeability transition pore complex in these processes.

Original languageEnglish
Pages (from-to)3465-3482
Number of pages18
JournalFrontiers in Bioscience
Volume14
Issue number9
DOIs
Publication statusPublished - 1 Jan 2009
Externally publishedYes

Keywords

  • Apoptosis
  • Calcium
  • Endoplasmic reticulum
  • Mitochondria
  • PTPC
  • Review

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