TY - JOUR
T1 - Short Communication Developmental Expression of Il-2-Receptor Light Chain (Cd25) in the Chicken Embryo
AU - Fedecka-Bruner, Barbara
AU - Vaigot, Pierre
AU - Lehmann, Anne
AU - Penninger, Josef
AU - MartíNez-A., Carlos
AU - Kroemer, Guido
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Thymocyte differentiation obeys the same fundamental principles in mammals as in avian species. This parallelism does not only affect the developmentally controlled acquisition of CD3, 4, 8, and TcR isotype expression, but also concerns CD25, the light chain of the interleukin-2 receptor (IL-2R). On chicken thymocytes, surface CD25, which is recognized by the monoclonal antibody INN Ch16, is first observed during day 11 of embryonic life, and peaks at day 14, when it is expressed by about one-third of all lymphoid cells. CD25 is found on subsets of all thymocyte populations as defined by TcRαβ, TcRγδ, 2, CD4, and CD8 expression, cortical or medullary localization, and is also present on a subset of intrathymic nursecell lymphocytes. These findings suggest phylogenetic conservation of the IL-2/IL-2R- triggered differentiation pathway previously described for mammalian species, thus underlining its probable functional importance.
AB - Thymocyte differentiation obeys the same fundamental principles in mammals as in avian species. This parallelism does not only affect the developmentally controlled acquisition of CD3, 4, 8, and TcR isotype expression, but also concerns CD25, the light chain of the interleukin-2 receptor (IL-2R). On chicken thymocytes, surface CD25, which is recognized by the monoclonal antibody INN Ch16, is first observed during day 11 of embryonic life, and peaks at day 14, when it is expressed by about one-third of all lymphoid cells. CD25 is found on subsets of all thymocyte populations as defined by TcRαβ, TcRγδ, 2, CD4, and CD8 expression, cortical or medullary localization, and is also present on a subset of intrathymic nursecell lymphocytes. These findings suggest phylogenetic conservation of the IL-2/IL-2R- triggered differentiation pathway previously described for mammalian species, thus underlining its probable functional importance.
KW - CD25
KW - IL-2 receptor
KW - T-cell ontogeny
KW - thymus
UR - http://www.scopus.com/inward/record.url?scp=0026306335&partnerID=8YFLogxK
U2 - 10.1155/1991/95302
DO - 10.1155/1991/95302
M3 - Article
C2 - 1840381
AN - SCOPUS:0026306335
SN - 1044-6672
VL - 1
SP - 237
EP - 242
JO - Developmental Immunology
JF - Developmental Immunology
IS - 3
ER -