Abstract
In anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALK+ ALCL), positive minimal residual disease (MRD+) after the first chemotherapy course was proven of strong prognostic significance. We aimed to validate these results in 138 French patients. Eighty-seven patients had a detectable minimal disseminated disease at diagnosis (MDD+). Early MRD assessment was performed in 33 of 87 patients and was positive in 18 and negative in 15 (MRD−). Three-year progression-free survival was significantly correlated with the MDD/MRD status: 81.1% in MDD−, 69.6% in MDD+/MRD−, and 15.2% in MDD+/MRD+ patients. In conclusion, we confirmed on an independent cohort that the MDD/MRD status has strong prognosis significance in ALK+ ALCL.
Original language | English |
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Article number | e28982 |
Journal | Pediatric Blood and Cancer |
Volume | 68 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1 Jun 2021 |
Keywords
- ALCL
- MRD
- anaplastic large cell lymphoma
- minimal residual disease