Abstract
Background: We investigated the survival of patients with a p16-positive N3 oropharyngeal squamous cell carcinoma (OPSCC) and the prognostic significance of patient, tumor, and treatment characteristics. Methods: We retrospectively reviewed the data of patients treated at our Cancer Center for a p16-positive N3 OPSCC between 2003 and 2016. End points were overall survival (OS) and progression-free survival (PFS). Results: A total of 29 patients were included. The 5-year OS and PFS were 67.5% and 59.1%, respectively. Smoking history above 10 pack-years and the absence of human papillomavirus DNA were associated with worse OS (P =.02 and P =.03, respectively) and PFS (P =.02 and P =.02, respectively). Induction chemotherapy or radical neck dissection were not associated with different treatment outcomes. Conclusion: Patients with an N3 p16-positive oropharyngeal cancer in our series had a 5-year OS rate of 67.5%. Smoking history and viral DNA were prognostic factors associated with survival.
Original language | English |
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Pages (from-to) | 1039-1045 |
Number of pages | 7 |
Journal | Head and Neck |
Volume | 41 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2019 |
Keywords
- N3
- human papillomavirus
- oropharyngeal neoplasms
- p16 immunohistochemistry
- smoking history