Soft tissue sarcomas in HIV-infected adult patients

K. Fizazi; J. Feuillard; A. Le Cesne; P. Terrier; M. Raphael; P. Pouillart; T. Tursz

doi:10.1016/0959-8049(96)00167-0

Soft tissue sarcomas in HIV-infected adult patients

K. Fizazi, J. Feuillard, A. Le Cesne, P. Terrier, M. Raphael, P. Pouillart, T. Tursz

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Abstract

Clinical and biological features of three HIV-infected adults with soft-tissue sarcoma are reported. Epstein-Barr Virus (EBV) detection was negative using in situ hybridisation, PCR analysis and Southern blot analysis in the two cases for which tumour samples were available, contrary to all previously reported paediatric cases. All three patients developed metastases. Chemotherapy was feasible but only afforded tumour stabilisation. The cause of death in all three cases was distant spread and not AIDS. Soft tissue sarcomas associated with HIV infection are not exclusively found in children, do not appear to be EBV-related in adult patients, and fare dismally despite vigorous therapy.

Original language	English
Pages (from-to)	1812-1814
Number of pages	3
Journal	European Journal of Cancer
Volume	32
Issue number	10
DOIs	https://doi.org/10.1016/0959-8049(96)00167-0
Publication status	Published - 1 Jan 1996

Keywords

Acquired immunodeficiency syndrome
Biology
Chemotherapy
Epstein-Barr virus
Human immunodeficiency virus
Leiomyosarcoma
Neoplasms
Rhabdomyosarcoma
Sarcoma

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title = "Soft tissue sarcomas in HIV-infected adult patients",

abstract = "Clinical and biological features of three HIV-infected adults with soft-tissue sarcoma are reported. Epstein-Barr Virus (EBV) detection was negative using in situ hybridisation, PCR analysis and Southern blot analysis in the two cases for which tumour samples were available, contrary to all previously reported paediatric cases. All three patients developed metastases. Chemotherapy was feasible but only afforded tumour stabilisation. The cause of death in all three cases was distant spread and not AIDS. Soft tissue sarcomas associated with HIV infection are not exclusively found in children, do not appear to be EBV-related in adult patients, and fare dismally despite vigorous therapy.",

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AU - Fizazi, K.

AU - Feuillard, J.

AU - Le Cesne, A.

AU - Terrier, P.

AU - Raphael, M.

AU - Pouillart, P.

AU - Tursz, T.

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AB - Clinical and biological features of three HIV-infected adults with soft-tissue sarcoma are reported. Epstein-Barr Virus (EBV) detection was negative using in situ hybridisation, PCR analysis and Southern blot analysis in the two cases for which tumour samples were available, contrary to all previously reported paediatric cases. All three patients developed metastases. Chemotherapy was feasible but only afforded tumour stabilisation. The cause of death in all three cases was distant spread and not AIDS. Soft tissue sarcomas associated with HIV infection are not exclusively found in children, do not appear to be EBV-related in adult patients, and fare dismally despite vigorous therapy.

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KW - Biology

KW - Chemotherapy

KW - Epstein-Barr virus

KW - Human immunodeficiency virus

KW - Leiomyosarcoma

KW - Neoplasms

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Soft tissue sarcomas in HIV-infected adult patients

Abstract

Keywords

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