Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel

Isabelle Uhoda; Najat Faska; Caroline Robert; Geert Cauwenbergh; Gérald E. Piérard

doi:10.1034/j.1600-0846.2002.10295.x

Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel

Isabelle Uhoda, Najat Faska, Caroline Robert, Geert Cauwenbergh, Gérald E. Piérard

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Background/aims: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. Methods: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. Results: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness Conclusion: The DMAE formulation under investigation increased skin firmness.

Original language	English
Pages (from-to)	164-167
Number of pages	4
Journal	Skin Research and Technology
Volume	8
Issue number	3
DOIs	https://doi.org/10.1034/j.1600-0846.2002.10295.x
Publication status	Published - 9 Oct 2002
Externally published	Yes

Keywords

Acetylcholine
Dimethylaminoethanol
Shear wave propagation
Tensile strength

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10.1034/j.1600-0846.2002.10295.x

Cite this

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title = "Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel",

abstract = "Background/aims: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. Methods: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. Results: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness Conclusion: The DMAE formulation under investigation increased skin firmness.",

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AU - Uhoda, Isabelle

AU - Faska, Najat

AU - Robert, Caroline

AU - Cauwenbergh, Geert

AU - Piérard, Gérald E.

PY - 2002/10/9

Y1 - 2002/10/9

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AB - Background/aims: Beyond subjective assessments, the effect of skin tensors is difficult to assess. The present 2-phase randomized double-blind split face study was designed to compare the effect of a gel containing 3% 2-dimethylaminoethanol (deanol, DMAE) with the same formulation without DMAE. Methods: In a first pilot study, sensorial assessments and measures of the skin distension under suction were performed in eight volunteers. In a second study conducted in 30 volunteers, shear wave propagation was measured. Results: Large interindividual variations precluded any significant finding in the first study. The DMAE formulation showed, however, a significant effect characterized by increased shear wave velocity in the direction where the mechanical anisotropy of skin showed looseness Conclusion: The DMAE formulation under investigation increased skin firmness.

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KW - Dimethylaminoethanol

KW - Shear wave propagation

KW - Tensile strength

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Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel

Abstract

Keywords

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