Spontaneous regression of multiple pulmonary metastases after radiofrequency ablation of a single metastasis

Pramod Rao, Bernard Escudier, Thierry De Baere

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    41 Citations (Scopus)

    Abstract

    We report two cases of spontaneous regression of multiple pulmonary metastases occurring after radiofrequency ablation (RFA) of a single lung metastasis. To the best of our knowledge, these are the first such cases reported. These two patients presented with lung metastases progressive despite treatment with interleukin-2, interferon, or sorafenib but were safely ablated with percutaneous RFA under computed tomography guidance. Percutaneous RFA allowed control of the targeted tumors for >1 year. Distant lung metastases presented an objective response despite the fact that they received no targeted local treatment. Local ablative techniques, such as RFA, induce the release of tumor-degradation product, which is probably responsible for an immunologic reaction that is able to produce a response in distant tumors.

    Original languageEnglish
    Pages (from-to)424-430
    Number of pages7
    JournalCardioVascular and Interventional Radiology
    Volume34
    Issue number2
    DOIs
    Publication statusPublished - 1 Apr 2011

    Keywords

    • Kidney cancer
    • Lung cancer
    • Lung metastasis
    • Radiofrequency

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