Abstract
The physicochemical stability and the compatibility between N-acetylcysteine (1 g/5 ml), betamethasone (4 mg/1 ml) and netilmicin (100 mg/1 ml) were studied at room temperature (25±2°C) over 1 h. During this study, drug concentrations were measured using three separate HPLC methods with UV detection at t=0, 5, 10, 20, 30, and 60 min. The pH of the mixture was determined. Degradation products of the drugs were assayed using HPLC. This study demonstrates the stability and compatibility of the mixture over 1 h at room temperature. The pinkish non-remnant coloration observed when pouring N-acetylcysteine into a recipient has no effect on the stability of the drug. Copyright (C) 1999 Elsevier Science B.V.
Original language | English |
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Pages (from-to) | 103-107 |
Number of pages | 5 |
Journal | International Journal of Pharmaceutics |
Volume | 190 |
Issue number | 1 |
DOIs | |
Publication status | Published - 10 Nov 1999 |
Externally published | Yes |
Keywords
- Betamethasone
- Compatibility
- N-Acetylcysteine
- Netilmicin
- Stability