Stability and compatibility of an aerosol mixture including N-acetylcysteine, netilmicin and betamethasone

A. Rieutord, P. Arnaud, J. F. Dauphin, F. Brion

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Abstract

The physicochemical stability and the compatibility between N-acetylcysteine (1 g/5 ml), betamethasone (4 mg/1 ml) and netilmicin (100 mg/1 ml) were studied at room temperature (25±2°C) over 1 h. During this study, drug concentrations were measured using three separate HPLC methods with UV detection at t=0, 5, 10, 20, 30, and 60 min. The pH of the mixture was determined. Degradation products of the drugs were assayed using HPLC. This study demonstrates the stability and compatibility of the mixture over 1 h at room temperature. The pinkish non-remnant coloration observed when pouring N-acetylcysteine into a recipient has no effect on the stability of the drug. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)103-107
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume190
Issue number1
DOIs
Publication statusPublished - 10 Nov 1999
Externally publishedYes

Keywords

  • Betamethasone
  • Compatibility
  • N-Acetylcysteine
  • Netilmicin
  • Stability

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