Stage II Seminoma: Why Chemotherapy Should Remain a Standard

Natacha Naoun, Alice Bernard-Tessier, Karim Fizazi

    Research output: Contribution to journalComment/debate

    2 Citations (Scopus)

    Abstract

    Chemotherapy (three cycles of bleomycin + etoposide + cisplatin or four of etoposide + cisplatin) cures the vast majority of stage II seminomas. Retroperitoneal lymph node dissection (RPLND) is safe in early-stage seminoma, but the risk of relapse is not negligible. Long-term chemotherapy side effects are a reality but may be reduced using de-escalation strategies such as in the SEMITEP trial design, motivated by growing interest in survivorship. RPLND may be an option for well-informed select patients who understand that it may be associated with a higher rate of relapse than with cisplatin-based chemotherapy. In any case, local and systemic treatment should not be performed outside high-volume centers.

    Original languageEnglish
    Pages (from-to)69-70
    Number of pages2
    JournalEuropean Urology Open Science
    Volume49
    DOIs
    Publication statusPublished - 1 Mar 2023

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