Standard of care of carcinomas on cancer of unknown primary site in 2016

Marc Antoine Benderra; Marius Ilié; Paul Hofman; Christophe Massard

doi:10.1016/j.bulcan.2016.05.003

Standard of care of carcinomas on cancer of unknown primary site in 2016

Marc Antoine Benderra, Marius Ilié, Paul Hofman, Christophe Massard

Research output: Contribution to journal › Short survey › peer-review

11 Citations (Scopus)

Abstract

Patients with Cancer of unknown primary (cup) represent 2–10%, and have disseminated cancers for which we cannot find the primary site despite the clinical, pathological and radiological exams at our disposal. Diagnosis is based on a thorough clinical and histopathologic examination as well as new imaging techniques. Several clinicopathologic entities requiring specific treatment can be identified. Genome sequencing and liquid biopsy (circulating tumor cells and tumor free DNA) could allow further advances in the diagnosis. Therapeutically, in addition to surgery, radiotherapy and chemotherapy, precision medicine provides new therapeutic approaches.

Translated title of the contribution	Prise en charge des carcinomes de primitif inconnu en 2016
Original language	English
Pages (from-to)	697-705
Number of pages	9
Journal	Bulletin du Cancer
Volume	103
Issue number	7-8
DOIs	https://doi.org/10.1016/j.bulcan.2016.05.003
Publication status	Published - 1 Jul 2016

Keywords

Cancer of unknown primary
Chemotherapy
Genome sequencing
Immunohistochemistry
Liquid biopsy
Precision medicine

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10.1016/j.bulcan.2016.05.003

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title = "Standard of care of carcinomas on cancer of unknown primary site in 2016",

abstract = "Patients with Cancer of unknown primary (cup) represent 2–10%, and have disseminated cancers for which we cannot find the primary site despite the clinical, pathological and radiological exams at our disposal. Diagnosis is based on a thorough clinical and histopathologic examination as well as new imaging techniques. Several clinicopathologic entities requiring specific treatment can be identified. Genome sequencing and liquid biopsy (circulating tumor cells and tumor free DNA) could allow further advances in the diagnosis. Therapeutically, in addition to surgery, radiotherapy and chemotherapy, precision medicine provides new therapeutic approaches.",

keywords = "Cancer of unknown primary, Chemotherapy, Genome sequencing, Immunohistochemistry, Liquid biopsy, Precision medicine",

author = "Benderra, {Marc Antoine} and Marius Ili{\'e} and Paul Hofman and Christophe Massard",

note = "Publisher Copyright: {\textcopyright} 2016 Soci{\'e}t{\'e} Fran{\c c}aise du Cancer",

year = "2016",

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doi = "10.1016/j.bulcan.2016.05.003",

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T1 - Standard of care of carcinomas on cancer of unknown primary site in 2016

AU - Benderra, Marc Antoine

AU - Ilié, Marius

AU - Hofman, Paul

AU - Massard, Christophe

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Patients with Cancer of unknown primary (cup) represent 2–10%, and have disseminated cancers for which we cannot find the primary site despite the clinical, pathological and radiological exams at our disposal. Diagnosis is based on a thorough clinical and histopathologic examination as well as new imaging techniques. Several clinicopathologic entities requiring specific treatment can be identified. Genome sequencing and liquid biopsy (circulating tumor cells and tumor free DNA) could allow further advances in the diagnosis. Therapeutically, in addition to surgery, radiotherapy and chemotherapy, precision medicine provides new therapeutic approaches.

AB - Patients with Cancer of unknown primary (cup) represent 2–10%, and have disseminated cancers for which we cannot find the primary site despite the clinical, pathological and radiological exams at our disposal. Diagnosis is based on a thorough clinical and histopathologic examination as well as new imaging techniques. Several clinicopathologic entities requiring specific treatment can be identified. Genome sequencing and liquid biopsy (circulating tumor cells and tumor free DNA) could allow further advances in the diagnosis. Therapeutically, in addition to surgery, radiotherapy and chemotherapy, precision medicine provides new therapeutic approaches.

KW - Cancer of unknown primary

KW - Chemotherapy

KW - Genome sequencing

KW - Immunohistochemistry

KW - Liquid biopsy

KW - Precision medicine

UR - http://www.scopus.com/inward/record.url?scp=84977622837&partnerID=8YFLogxK

U2 - 10.1016/j.bulcan.2016.05.003

DO - 10.1016/j.bulcan.2016.05.003

M3 - Short survey

C2 - 27372228

AN - SCOPUS:84977622837

SN - 0007-4551

VL - 103

SP - 697

EP - 705

JO - Bulletin du Cancer

JF - Bulletin du Cancer

IS - 7-8

ER -

Standard of care of carcinomas on cancer of unknown primary site in 2016

Abstract

Keywords

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