Subversion of calreticulin exposure as a strategy of immune escape

Guido Kroemer; Laurence Zitvogel

doi:10.1016/j.ccell.2021.01.014

Subversion of calreticulin exposure as a strategy of immune escape

Guido Kroemer, Laurence Zitvogel

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the “eat me” signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.

Original language	English
Pages (from-to)	449-451
Number of pages	3
Journal	Cancer Cell
Volume	39
Issue number	4
DOIs	https://doi.org/10.1016/j.ccell.2021.01.014
Publication status	Published - 12 Apr 2021

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10.1016/j.ccell.2021.01.014

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title = "Subversion of calreticulin exposure as a strategy of immune escape",

abstract = "In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the “eat me” signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.",

author = "Guido Kroemer and Laurence Zitvogel",

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AU - Zitvogel, Laurence

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N2 - In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the “eat me” signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.

AB - In this issue, Lin et al. report that, in malignant cells, stanniocalcin-1 (STC1) prevents the cell surface exposure of the “eat me” signal calreticulin, thereby avoiding phagocytosis by antigen-presenting cells. STC1 overexpression joins an arsenal of mechanisms through which tumor cells suppress calreticulin exposure and escape from immunosurveillance.

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SN - 1535-6108

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JO - Cancer Cell

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ER -

Subversion of calreticulin exposure as a strategy of immune escape

Abstract

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