Abstract
The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATPdegrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.
Original language | English |
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Pages (from-to) | 393-395 |
Number of pages | 3 |
Journal | OncoImmunology |
Volume | 1 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 Nov 2012 |
Keywords
- ATP release
- Anthracyclines
- Cancer
- Immunogenic cell death
- Macroautophagy
- Oxaliplatin