Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

Mickaël Michaud, Abdul Qader Sukkurwala, Isabelle Martins, Shensi Shen, Laurence Zitvogel, Guido Kroemer

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    53 Citations (Scopus)

    Abstract

    The efficacy of antineoplastic chemotherapies with anthracyclines or oxaliplatin relies on the induction of immunogenic cell death, thus provoking an anticancer immune response. Recently, we observed that overexpression of CD39, an ATPdegrading enzyme expressed on the cell surface, abolishes the immunogenicity of cell death, thus rendering cancers resistant against chemotherapy.

    Original languageEnglish
    Pages (from-to)393-395
    Number of pages3
    JournalOncoImmunology
    Volume1
    Issue number3
    DOIs
    Publication statusPublished - 1 Nov 2012

    Keywords

    • ATP release
    • Anthracyclines
    • Cancer
    • Immunogenic cell death
    • Macroautophagy
    • Oxaliplatin

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