Abstract
Human herpes virus-6 primary infection generally occurs during the first three years of childhood and is generally asymptomatic. The virus has been identified as the causal agent of exanthemum subitum in children or mononucleosis-like disease in adults, and may also cause several disorders in immunocompromised patients. We report a clinical case of acute rejection observed 29 days after orthotopic liver transplantation in a 22-month-old child associated with acute hepatitis and a hemophagocytic syndrome on day 38. Human herpes virus-6 primary infection was identified based on several virological tests: seroconversion, detection of viral DNA in bone marrowy and peripheral blood after polymerase chain reaction, and detection of viral replication in peripheral blood. Tests for Epstein-Barr virus, cytomegalovirus or Parvovirus B19 infections were negative. After treatment by ganciclovir (Cymévan®), clinical status improved.
| Translated title of the contribution | Hemophagocytic syndrome in primary human herpes virus-6 infection: A rare condition after liver transplantation |
|---|---|
| Original language | French |
| Pages (from-to) | 1227-1228 |
| Number of pages | 2 |
| Journal | Gastroenterologie Clinique et Biologique |
| Volume | 24 |
| Issue number | 12 |
| Publication status | Published - 1 Dec 2000 |
| Externally published | Yes |