TY - JOUR
T1 - T-cell-based immunotherapy
T2 - Adoptive cell transfer and checkpoint inhibition
AU - Houot, Roch
AU - Schultz, Liora Michal
AU - Marabelle, Aurélien
AU - Kohrt, Holbrook
N1 - Publisher Copyright:
© 2015 American Association for Cancer Research.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell-based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell-based strategies currently in clinical trials and put their applications, present and future, into perspective.
AB - Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell-based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell-based strategies currently in clinical trials and put their applications, present and future, into perspective.
UR - http://www.scopus.com/inward/record.url?scp=84962039029&partnerID=8YFLogxK
U2 - 10.1158/2326-6066.CIR-15-0190
DO - 10.1158/2326-6066.CIR-15-0190
M3 - Article
C2 - 26438444
AN - SCOPUS:84962039029
SN - 2326-6066
VL - 3
SP - 1115
EP - 1122
JO - Cancer Immunology Research
JF - Cancer Immunology Research
IS - 10
ER -