TY - JOUR
T1 - The autophagic network and cancer
AU - Rybstein, Marissa D.
AU - Bravo-San Pedro, José Manuel
AU - Kroemer, Guido
AU - Galluzzi, Lorenzo
N1 - Publisher Copyright:
© 2018 The Author(s).
PY - 2018/3/1
Y1 - 2018/3/1
N2 - Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism and cope with microenvironmental perturbations. Moreover, autophagy connects cellular adaptation with extracellular circuitries that impinge on immunity and metabolism. As it links transformed and non-transformed components of the tumour microenvironment, such an autophagic network is important for cancer initiation, progression and response to therapy. Here, we discuss the mechanisms whereby the autophagic network interfaces with multiple aspects of malignant disease.
AB - Mammalian cells harness autophagy to eliminate physiological byproducts of metabolism and cope with microenvironmental perturbations. Moreover, autophagy connects cellular adaptation with extracellular circuitries that impinge on immunity and metabolism. As it links transformed and non-transformed components of the tumour microenvironment, such an autophagic network is important for cancer initiation, progression and response to therapy. Here, we discuss the mechanisms whereby the autophagic network interfaces with multiple aspects of malignant disease.
UR - http://www.scopus.com/inward/record.url?scp=85042586202&partnerID=8YFLogxK
U2 - 10.1038/s41556-018-0042-2
DO - 10.1038/s41556-018-0042-2
M3 - Review article
C2 - 29476153
AN - SCOPUS:85042586202
SN - 1465-7392
VL - 20
SP - 243
EP - 251
JO - Nature Cell Biology
JF - Nature Cell Biology
IS - 3
ER -