TY - JOUR
T1 - The ECLIPSE Study
T2 - Efficacy of Cryoablation on Metastatic Lung Tumors With a 5-Year Follow-Up
AU - de Baère, Thierry
AU - Woodrum, David
AU - Tselikas, Lambros
AU - Abtin, Fereidoun
AU - Littrup, Peter
AU - Deschamps, Frederic
AU - Suh, Robert
AU - Aoun, Hussein D.
AU - Callstrom, Matthew
N1 - Publisher Copyright:
© 2021 International Association for the Study of Lung Cancer
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Introduction: The ECLIPSE study aimed to evaluate the feasibility and efficacy of cryoablation (CA) for local tumor control in patients with pulmonary metastatic disease in 5 years of follow-up. Methods: ECLIPSE was a prospective, multicenter, single-arm study that included patients treated with CA if they had one to five metastatic lung tumors, each with a diameter of less than or equal to 3.5 cm. Patients were followed up in the course of 5 years. The primary end point was local tumor control, both per tumor and per patient; secondary end points included cancer-specific survival, overall survival, and quality of life (QoL). QoL was evaluated using the Karnofsky Performance Score, the Eastern Cooperative Oncology Group performance score, and the Short Form-12 health survey. Results: The study included 40 patients across four sites (three in United States and one in Europe). A total of 60 metastatic pulmonary tumors were treated with 48 CA procedures. Overall local tumor control rates were 87.9% (29 of 33) and 79.2% (19 of 24) per tumor, 83.3% (20 of 24) and 75.0% (15 of 20) per patient, at 3 and 5 years, respectively. A total of five treated patients had local progression throughout the duration of the study. Disease-specific survival rate was 74.8% at 3 years and 55.3% at 5 years, whereas overall survival at 3 and 5 years was 63.2% and 46.7%, respectively. Patient QoL scores did not reach statistical significance. Conclusions: CA is an effective means of long-term local tumor control in patients with metastatic pulmonary tumors.
AB - Introduction: The ECLIPSE study aimed to evaluate the feasibility and efficacy of cryoablation (CA) for local tumor control in patients with pulmonary metastatic disease in 5 years of follow-up. Methods: ECLIPSE was a prospective, multicenter, single-arm study that included patients treated with CA if they had one to five metastatic lung tumors, each with a diameter of less than or equal to 3.5 cm. Patients were followed up in the course of 5 years. The primary end point was local tumor control, both per tumor and per patient; secondary end points included cancer-specific survival, overall survival, and quality of life (QoL). QoL was evaluated using the Karnofsky Performance Score, the Eastern Cooperative Oncology Group performance score, and the Short Form-12 health survey. Results: The study included 40 patients across four sites (three in United States and one in Europe). A total of 60 metastatic pulmonary tumors were treated with 48 CA procedures. Overall local tumor control rates were 87.9% (29 of 33) and 79.2% (19 of 24) per tumor, 83.3% (20 of 24) and 75.0% (15 of 20) per patient, at 3 and 5 years, respectively. A total of five treated patients had local progression throughout the duration of the study. Disease-specific survival rate was 74.8% at 3 years and 55.3% at 5 years, whereas overall survival at 3 and 5 years was 63.2% and 46.7%, respectively. Patient QoL scores did not reach statistical significance. Conclusions: CA is an effective means of long-term local tumor control in patients with metastatic pulmonary tumors.
KW - Cryoablation
KW - Lung metastasis
KW - Percutaneous ablation
KW - Tumor control
UR - http://www.scopus.com/inward/record.url?scp=85117923048&partnerID=8YFLogxK
U2 - 10.1016/j.jtho.2021.07.021
DO - 10.1016/j.jtho.2021.07.021
M3 - Article
C2 - 34384914
AN - SCOPUS:85117923048
SN - 1556-0864
VL - 16
SP - 1840
EP - 1849
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 11
ER -