TY - JOUR
T1 - The elusive “hunger protein”
T2 - an appetite-stimulatory factor that is overabundant in human obesity
AU - Bravo-San Pedro, José Manuel
AU - Sica, Valentina
AU - Kroemer, Guido
N1 - Publisher Copyright:
© 2019, © 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2019/11/2
Y1 - 2019/11/2
N2 - Paradoxically, most if not all previously known appetite-stimulatory hormones are downregulated in human obesity, reflecting failing homeostatic circuitries. Recently, we discovered that acyl-coenzyme-A binding protein/diazepam-binding inhibitor (ACBP/DBI) acts as a lipogenic and appetite stimulator, when systemically injected into mice. ACBP/DBI plasma levels are also elevated in obese subjects, supporting the notion that it may represent the elusive “hunger protein” that explains overeating in human obesity.
AB - Paradoxically, most if not all previously known appetite-stimulatory hormones are downregulated in human obesity, reflecting failing homeostatic circuitries. Recently, we discovered that acyl-coenzyme-A binding protein/diazepam-binding inhibitor (ACBP/DBI) acts as a lipogenic and appetite stimulator, when systemically injected into mice. ACBP/DBI plasma levels are also elevated in obese subjects, supporting the notion that it may represent the elusive “hunger protein” that explains overeating in human obesity.
KW - Aging
KW - anorexia
KW - metabolism
KW - obesity
UR - http://www.scopus.com/inward/record.url?scp=85074077169&partnerID=8YFLogxK
U2 - 10.1080/23723556.2019.1667193
DO - 10.1080/23723556.2019.1667193
M3 - Comment/debate
AN - SCOPUS:85074077169
SN - 2372-3556
VL - 6
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 6
M1 - e1667193
ER -