The host-tumor immune conflict: From immunosuppression to resistance and destruction

Salem Chouaib, Carine Asselin-Paturel, Fathia Mami-Chouaib, Anne Caignard, Jean Yves Blay

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    347 Citations (Scopus)

    Abstract

    A successful immune response against a tumor is dependent on the cytokine repertoire present at the tumor site. Salem Chouaib and colleagues discuss evidence that, to escape the immune system, tumor cells not only produce immunosuppressive cytokines but also employ strategies involving altered susceptibility to tumor necrosis factor and Fas cytotoxic pathways and, in some circumstances, use of the Fas ligand to neutralize effector cells.

    Original languageEnglish
    Pages (from-to)493-497
    Number of pages5
    JournalImmunology Today
    Volume18
    Issue number10
    DOIs
    Publication statusPublished - 1 Oct 1997

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