The multi-factorial pathogenesis of autoimmune disease

G. Wick; G. Krömer; N. Neu; R. Fässler; A. Ziemiecki; R. G. Müller; M. Ginzel; I. Béládi; T. Kühr; K. Hála

doi:10.1016/0165-2478(87)90154-4

The multi-factorial pathogenesis of autoimmune disease

G. Wick, G. Krömer, N. Neu, R. Fässler, A. Ziemiecki, R. G. Müller, M. Ginzel, I. Béládi, T. Kühr, K. Hála

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Development of organ-specific autoimmune diseases depends on both an abnormal immune regulation and a genetically determined primary susceptibility of the target organ to the autoimmune attack. In addition to the essential genetically determined prerequisites there are also facultative, modulating factors that influence the outcome of an autoimmune disease. This concept is exemplified in the Obese strain (OS) chicken model which develops a spontaneous autoimmune thyroiditis closely resembling human Hashimoto disease. Three modulating factors are specifically addressed, viz. (a) the lower threshold of OS thyroid epithelial cells for the γ-interferon-induced MHC class II antigen expression as compared to normal controls, (b) the decreased glucocorticoid tonus of the OS and (c) the presence of a new endogenous virus (ev 22) locus in the OS that has so far not been found in any normal strain and which seems to influence the glucocorticoid-mediated immunoregulatory process.

Original language	English
Pages (from-to)	249-257
Number of pages	9
Journal	Immunology Letters
Volume	16
Issue number	3-4
DOIs	https://doi.org/10.1016/0165-2478(87)90154-4
Publication status	Published - 1 Jan 1987
Externally published	Yes

Keywords

Autoimmune disease
Autoimmune thyroiditis
Endogenous virus
Glucocorticoids
MHC class II antigens
OS chicken

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10.1016/0165-2478(87)90154-4

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title = "The multi-factorial pathogenesis of autoimmune disease",

abstract = "Development of organ-specific autoimmune diseases depends on both an abnormal immune regulation and a genetically determined primary susceptibility of the target organ to the autoimmune attack. In addition to the essential genetically determined prerequisites there are also facultative, modulating factors that influence the outcome of an autoimmune disease. This concept is exemplified in the Obese strain (OS) chicken model which develops a spontaneous autoimmune thyroiditis closely resembling human Hashimoto disease. Three modulating factors are specifically addressed, viz. (a) the lower threshold of OS thyroid epithelial cells for the γ-interferon-induced MHC class II antigen expression as compared to normal controls, (b) the decreased glucocorticoid tonus of the OS and (c) the presence of a new endogenous virus (ev 22) locus in the OS that has so far not been found in any normal strain and which seems to influence the glucocorticoid-mediated immunoregulatory process.",

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author = "G. Wick and G. Kr{\"o}mer and N. Neu and R. F{\"a}ssler and A. Ziemiecki and M{\"u}ller, {R. G.} and M. Ginzel and I. B{\'e}l{\'a}di and T. K{\"u}hr and K. H{\'a}la",

note = "Funding Information: This work was supported by the Austrian Research Council (Project no. S-41/05) and the Jubil~iumsfond of the Austrian National Bank (Grant no. 2784). We acknowledge the competent technical assistance of Mrs. Pia-Ulrike Mfiller, and the secretarial help of Mrs. Anita Fuchs.",

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AU - Krömer, G.

AU - Neu, N.

AU - Fässler, R.

AU - Ziemiecki, A.

AU - Müller, R. G.

AU - Ginzel, M.

AU - Béládi, I.

AU - Kühr, T.

AU - Hála, K.

N1 - Funding Information: This work was supported by the Austrian Research Council (Project no. S-41/05) and the Jubil~iumsfond of the Austrian National Bank (Grant no. 2784). We acknowledge the competent technical assistance of Mrs. Pia-Ulrike Mfiller, and the secretarial help of Mrs. Anita Fuchs.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Development of organ-specific autoimmune diseases depends on both an abnormal immune regulation and a genetically determined primary susceptibility of the target organ to the autoimmune attack. In addition to the essential genetically determined prerequisites there are also facultative, modulating factors that influence the outcome of an autoimmune disease. This concept is exemplified in the Obese strain (OS) chicken model which develops a spontaneous autoimmune thyroiditis closely resembling human Hashimoto disease. Three modulating factors are specifically addressed, viz. (a) the lower threshold of OS thyroid epithelial cells for the γ-interferon-induced MHC class II antigen expression as compared to normal controls, (b) the decreased glucocorticoid tonus of the OS and (c) the presence of a new endogenous virus (ev 22) locus in the OS that has so far not been found in any normal strain and which seems to influence the glucocorticoid-mediated immunoregulatory process.

AB - Development of organ-specific autoimmune diseases depends on both an abnormal immune regulation and a genetically determined primary susceptibility of the target organ to the autoimmune attack. In addition to the essential genetically determined prerequisites there are also facultative, modulating factors that influence the outcome of an autoimmune disease. This concept is exemplified in the Obese strain (OS) chicken model which develops a spontaneous autoimmune thyroiditis closely resembling human Hashimoto disease. Three modulating factors are specifically addressed, viz. (a) the lower threshold of OS thyroid epithelial cells for the γ-interferon-induced MHC class II antigen expression as compared to normal controls, (b) the decreased glucocorticoid tonus of the OS and (c) the presence of a new endogenous virus (ev 22) locus in the OS that has so far not been found in any normal strain and which seems to influence the glucocorticoid-mediated immunoregulatory process.

KW - Autoimmune disease

KW - Autoimmune thyroiditis

KW - Endogenous virus

KW - Glucocorticoids

KW - MHC class II antigens

KW - OS chicken

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JO - Immunology Letters

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ER -

The multi-factorial pathogenesis of autoimmune disease

Abstract

Keywords

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