Abstract
Granulysin is a cytolytic and proinflammatory peptide contained in the cytotoxic granules of NK cells and CTL. Unexpectedly, granulysin also recruits and activates dendritic cells via TLR4/Myd88, playing the role of an immune adjuvant. Hence, in contrast to classical alarmins released by early leukocytes, granulysin is the first alarmin to be released from lymphocytes.
Original language | English |
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Pages (from-to) | 3379-3380 |
Number of pages | 2 |
Journal | Blood |
Volume | 116 |
Issue number | 18 |
DOIs |
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Publication status | Published - 4 Nov 2010 |