The permeability transition pore complex in cancer cell death

C. Brenner, S. Grimm

Research output: Contribution to journalReview articlepeer-review

179 Citations (Scopus)

Abstract

The permeability transition pore (PTP) is a multi-protein complex at contact sites of the inner with the outer mitochondrial membrane. Research over the past years has led to the concept that the PTP occupies a central role in cell death induction. Numerous apoptosis signals convert this protein aggregate into an unspecific pore, thus activating mitochondria for the cellular self-destruction process. Here, we describe the evidence for this and the various approaches being undertaken to elucidate its subunit composition and mode of regulation. In particular, we review data that indicate a role of specific PTP subunits for apoptosis inhibition during tumorigenesis.

Original languageEnglish
Pages (from-to)4744-4756
Number of pages13
JournalOncogene
Volume25
Issue number34
DOIs
Publication statusPublished - 7 Aug 2006
Externally publishedYes

Keywords

  • Adenine nucleotide translocator
  • Apoptosis
  • Cyclophilin D
  • Mitochondria
  • VDAC

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