The role of sex and gender in the diagnosis and treatment of lung cancer: the 6th ICAPEM Annual Symposium

Nuria Viñolas; Laura Mezquita; Jesús Corral; Manuel Cobo; Francisco Gil-Moncayo; Luis Paz-Ares; Jordi Remon; María Rodríguez; Alberto Ruano-Raviña; Esther Conde; Margarita Majem; Pilar Garrido; Enriqueta Felip; Dolores Isla; Javier de Castro

doi:10.1007/s12094-023-03262-x

The role of sex and gender in the diagnosis and treatment of lung cancer: the 6th ICAPEM Annual Symposium

Nuria Viñolas, Laura Mezquita, Jesús Corral, Manuel Cobo, Francisco Gil-Moncayo, Luis Paz-Ares, Jordi Remon, María Rodríguez, Alberto Ruano-Raviña, Esther Conde, Margarita Majem, Pilar Garrido, Enriqueta Felip, Dolores Isla, Javier de Castro

Research output: Contribution to journal › Article › peer-review

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Abstract

The incidence and mortality of lung cancer in women are rising, with both increasing by 124% between 2003 and 2019. The main risk factor for lung cancer is tobacco use, but indoor radon gas exposure is one of the leading causes in nonsmokers. The most recent evidence demonstrates that multiple factors can make women more susceptible to harm from these risk factors or carcinogens. For this consensus statement, the Association for Lung Cancer Research in Women (ICAPEM) invited a group of lung cancer experts to perform a detailed gender-based analysis of lung cancer. Clinically, female patients have different lung cancer profiles, and most actionable driver alterations are more prevalent in women, particularly in never-smokers. Additionally, the impact of certain therapies seems to be different. In the future, it will be necessary to carry out specific studies to improve the understanding of the role of certain biomarkers and gender in the prognosis and evolution of lung cancer.

Original language	English
Pages (from-to)	352-362
Number of pages	11
Journal	Clinical and Translational Oncology
Volume	26
Issue number	2
DOIs	https://doi.org/10.1007/s12094-023-03262-x
Publication status	Published - 1 Feb 2024
Externally published	Yes

Keywords

Gender
Lung cancer
Radon gas
Tobacco
Women

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10.1007/s12094-023-03262-x

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Viñolas, N., Mezquita, L., Corral, J., Cobo, M., Gil-Moncayo, F., Paz-Ares, L., Remon, J., Rodríguez, M., Ruano-Raviña, A., Conde, E., Majem, M., Garrido, P., Felip, E., Isla, D., & de Castro, J. (2024). The role of sex and gender in the diagnosis and treatment of lung cancer: the 6th ICAPEM Annual Symposium. Clinical and Translational Oncology, 26(2), 352-362. https://doi.org/10.1007/s12094-023-03262-x

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abstract = "The incidence and mortality of lung cancer in women are rising, with both increasing by 124% between 2003 and 2019. The main risk factor for lung cancer is tobacco use, but indoor radon gas exposure is one of the leading causes in nonsmokers. The most recent evidence demonstrates that multiple factors can make women more susceptible to harm from these risk factors or carcinogens. For this consensus statement, the Association for Lung Cancer Research in Women (ICAPEM) invited a group of lung cancer experts to perform a detailed gender-based analysis of lung cancer. Clinically, female patients have different lung cancer profiles, and most actionable driver alterations are more prevalent in women, particularly in never-smokers. Additionally, the impact of certain therapies seems to be different. In the future, it will be necessary to carry out specific studies to improve the understanding of the role of certain biomarkers and gender in the prognosis and evolution of lung cancer.",

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doi = "10.1007/s12094-023-03262-x",

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Viñolas, N, Mezquita, L, Corral, J, Cobo, M, Gil-Moncayo, F, Paz-Ares, L, Remon, J, Rodríguez, M, Ruano-Raviña, A, Conde, E, Majem, M, Garrido, P, Felip, E, Isla, D & de Castro, J 2024, 'The role of sex and gender in the diagnosis and treatment of lung cancer: the 6th ICAPEM Annual Symposium', Clinical and Translational Oncology, vol. 26, no. 2, pp. 352-362. https://doi.org/10.1007/s12094-023-03262-x

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AU - Gil-Moncayo, Francisco

AU - Paz-Ares, Luis

AU - Remon, Jordi

AU - Rodríguez, María

AU - Ruano-Raviña, Alberto

AU - Conde, Esther

AU - Majem, Margarita

AU - Garrido, Pilar

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AU - de Castro, Javier

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AB - The incidence and mortality of lung cancer in women are rising, with both increasing by 124% between 2003 and 2019. The main risk factor for lung cancer is tobacco use, but indoor radon gas exposure is one of the leading causes in nonsmokers. The most recent evidence demonstrates that multiple factors can make women more susceptible to harm from these risk factors or carcinogens. For this consensus statement, the Association for Lung Cancer Research in Women (ICAPEM) invited a group of lung cancer experts to perform a detailed gender-based analysis of lung cancer. Clinically, female patients have different lung cancer profiles, and most actionable driver alterations are more prevalent in women, particularly in never-smokers. Additionally, the impact of certain therapies seems to be different. In the future, it will be necessary to carry out specific studies to improve the understanding of the role of certain biomarkers and gender in the prognosis and evolution of lung cancer.

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The role of sex and gender in the diagnosis and treatment of lung cancer: the 6th ICAPEM Annual Symposium

Abstract

Keywords

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