@article{065ee3f07ce946b19028ea1fa162ed9f,
title = "The sphingosine 1-phosphate receptor 1 causes tissue retention by inhibiting the entry of peripheral tissue T lymphocytes into afferent lymphatics",
abstract = "Although much is known about the migration of T cells from blood to lymph nodes, less is known about the mechanisms regulating the migration of T cells from tissues into lymph nodes through afferent lymphatics. Here we investigated T cell egress from nonlymphoid tissues into afferent lymph in vivo and developed an experimental model to recapitulate this process in vitro. Agonism of sphingosine 1-phosphate receptor 1 inhibited the entry of tissue T cells into afferent lymphatics in homeostatic and inflammatory conditions and caused the arrest, mediated at least partially by interactions of the integrin LFA-1 with its ligand ICAM-1 and of the integrin VLA-4 with its ligand VCAM-1, of polarized T cells at the basal surface of lymphatic but not blood vessel endothelium. Thus, the increased sphingosine 1-phosphate present in inflamed peripheral tissues may induce T cell retention and suppress T cell egress.",
author = "Ledgerwood, {Levi G.} and Girdhari Lal and Nan Zhang and Alexandre Garin and Esses, {Steven J.} and Florent Ginhoux and Miriam Merad and Helene Peche and Lira, {Sergio A.} and Yaozhong Ding and Yu Yang and Xingxuan He and Schuchman, {Edward H.} and Allende, {Maria L.} and Ochando, {Jordi C.} and Bromberg, {Jonathan S.}",
note = "Funding Information: We thank P. Heeger and R. Jessberger for discussions; V. Brinkmann for reagents; J. Lowe (Cleveland Clinic) for mice lacking fucosyltransferase IV and VII; R. Proia (National Institutes of Health) for S1P1loxP/loxP Lck-Cre mice and littermate controls; and M. Mao, D. Chen, A.M. Ledgerwood, the Mount Sinai Microscopy Core and the Mount Sinai Microarray Facility. Supported by the National Institutes of Health (AI41428 and AI62765 to J.S.B., and DK67381 to S.A.L.), the Emerald Foundation (J.S.B.), the Juvenile Diabetes Research Foundation (1-2005-16 to J.S.B.), Ministerio de Educaci{\'o}n y Ciencia, Spain (SAF2007-63579 to J.C.O.) and the Howard Hughes Medical Institute (L.G.L.).",
year = "2008",
month = jan,
day = "1",
doi = "10.1038/ni1534",
language = "English",
volume = "9",
pages = "42--53",
journal = "Nature Immunology",
issn = "1529-2908",
number = "1",
}