@article{b20de4fa52354377b92bf813efc97b01,
title = "The TEL gene products: Nuclear phosphoproteins with DNA binding properties",
abstract = "The human TEL gene is involved in several 12p13 chromosomal abnormalities present in various human hematological malignancies, the most frequent being the t(12;21)(p13;q22), specific for childhood acute lymphoblastic leukemia. The predicted product of TEL harbours an amino acid region similar to the ETS DNA binding domain. We now report the isolation of the murine TEL cDNA arid the characterization of the human TEL proteins. Human and murine TEL proteins are particularly homologous within their aminoterminal regions and their ETS domains. TEL proteins are nuclear and display specific DNA binding activity toward classical ETS binding sites. In addition, we show that TEL mRNAs initiate translation at either of the two first in-frame ATGs (codon 1 and 43) to encode 50 kDa and 57 kDa TEL proteins. In vivo, each of these primary translational products is modified by multiple phosphorylation events.",
keywords = "ETS, Leukemia, TEL, Transcription factor, Translocation",
author = "H{\'e}l{\`e}ne Poirel and C{\'e}cile Oury and Cl{\'e}mence Carron and Estelle Duprez and Yacine Laabi and Andr{\'e}as Tsapis and Romana, {Serge P.} and Martine Mauchauffe and {Le Coniat}, Maryvonne and Roland Berger and Jacques Ghysdael and Bernard, {Olivier A.}",
note = "Funding Information: We thank Dr SJ Pirruccello for the PBEI cell line, M Schmit for help in immunofluorescence analysis and V Dellavalle for cell culture. SPR is supported by a fellowship from the {\textquoteleft}Centre int{\'e}gr{\'e} de la dr{\'e}panocytose{\textquoteright}, Guadeloupe, French West Indies and HP by a fellowship from the {\textquoteleft}Ligue Nationale Contre le Cancer{\textquoteright}. This work was supported by the {\textquoteleft}Fondation pour la Recherche m{\'e}dicle{\textquoteright}, the {\textquoteleft}Ligue Nationale Contre le Cancer{\textquoteright}, the {\textquoteleft}Association pour la Recherche contre le Cancer{\textquoteright}, the {\textquoteleft}Institut National pour la recherche M{\'e}dicale{\textquoteright} (INSERM), the Institut Curie and the {\textquoteleft}Centre National de la Recherche scientifique{\textquoteright} (CNRS).",
year = "1997",
month = jan,
day = "1",
doi = "10.1038/sj.onc.1200829",
language = "English",
volume = "14",
pages = "349--357",
journal = "Oncogene",
issn = "0950-9232",
number = "3",
}