Therapeutic Strategies to Overcome ALK Resistance in Cancer

Luc Friboulet

Research output: Book/ReportBookpeer-review

Abstract

Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment.

Original languageEnglish
PublisherElsevier
Number of pages195
ISBN (Electronic)9780128217740
ISBN (Print)9780128217795
DOIs
Publication statusPublished - 1 Jan 2021
Externally publishedYes

Cite this