Traitement systémique des métastases cérébrales de mélanome

Translated title of the contribution: Systemic treatment of melanoma brain metastases

Rhun Le Rhun, C. Mateus, L. Mortier, F. Dhermain, B. Guillot, J. J. Grob, C. Lebbe, M. Thomas, T. Jouary, M. T. Leccia, C. Robert

    Research output: Contribution to journalShort surveypeer-review

    3 Citations (Scopus)

    Abstract

    Melanomas have a high rate of brain metastases. Both the functional prognosis and the overall survival are poor in these patients. Until now, surgery and radiotherapy represented the two main modalities of treatment. Nevertheless, due to the improvement in the management of the extracerebral melanoma, the systemic treatment may be an option in patients with brain metastases. Immunotherapy with anti-CTLA4 (cytotoxic T-lymphocyte-associated protein 4) -ipilimumab- or BRAF (serine/threonine-protein kinase B-raf) inhibitors -vemurafenib, dabrafenib- has shown efficacy in the management of brain metastases in a- or pauci-symptomatic patients. Studies are ongoing with anti-PD1 (programmed cell death 1) and combinations of targeted therapies associating anti-RAF (raf proto-oncogene, serine/threonine kinase) and anti-MEK (mitogen-activated protein kinase kinase).

    Translated title of the contributionSystemic treatment of melanoma brain metastases
    Original languageFrench
    Pages (from-to)48-54
    Number of pages7
    JournalCancer/Radiotherapie
    Volume19
    Issue number1
    DOIs
    Publication statusPublished - 1 Feb 2015

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