Traitements néoadjuvants des cancers bronchiques non à petites cellules

Translated title of the contribution: Neoadjuvant chemotherapy in non small cell lung cancer

Benjamin Besse, Stéphane Vignot, Thierry Le Chevalier

    Research output: Contribution to journalReview articlepeer-review

    2 Citations (Scopus)

    Abstract

    Standards of care for non small cell lung cancer (NSCLC) are not, yet, totally established. The role of induction chemotherapy is still debated while it has been established that adjuvant cisplatin based chemotherapy improve overall survival in completely resected patients. We will review the feasibility and efficacy of induction chemotherapy for patients with early-stage and locally advanced NSCLC, particularly with N2 disease. In the neoadjuvant setting, a 32 to 60% response rate is awaited considering the high treatment compliance. Near to 10% pathologic complete response rate is reported. Nevertheless, no large randomised phase III trial has demonstrated that induction chemotherapy could prolong patients overall survival. Suboptimal cytotoxic combinations and an increased surgical mortality might explain this result. Studies suggested that patient's subgroups (as downstaged N2 disease) could benefit from induction treatment. This still need to be confirmed in randomised trial and meta-analysis based on individual data.

    Translated title of the contributionNeoadjuvant chemotherapy in non small cell lung cancer
    Original languageFrench
    Pages (from-to)1087-1092
    Number of pages6
    JournalBulletin du Cancer
    Volume93
    Issue number11
    DOIs
    Publication statusPublished - 1 Nov 2006

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