Abstract
The regulation of efficacy of a chemical synapse at the postsynaptic level is discussed in terms of the reversible allosteric transitions of the receptor for the neurotransmitter. The proposed model accounts for the regulation of a synapse by its own state of activity and by that of neighbouring synapses on the same neuron. The model predicts persisting changes of efficacy in the time-scale of seconds-minutes compatible with short-term memory processes following, in particular, the scheme of classical conditioning.
Translated title of the contribution | Molecular model of the regulation of chemical synapse efficiency at the postsynaptic level |
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Original language | French |
Pages (from-to) | 665-670 |
Number of pages | 6 |
Journal | Comptes Rendus de l'Academie des Sciences - Serie III |
Volume | 295 |
Issue number | 12 |
Publication status | Published - 6 Dec 1982 |