Un modèle moléculaire de régulation d'efficacité au niveau postsynaptique d'une synapse chimique.

Translated title of the contribution: Molecular model of the regulation of chemical synapse efficiency at the postsynaptic level

T. Heidmann, J. P. Changeux

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    Abstract

    The regulation of efficacy of a chemical synapse at the postsynaptic level is discussed in terms of the reversible allosteric transitions of the receptor for the neurotransmitter. The proposed model accounts for the regulation of a synapse by its own state of activity and by that of neighbouring synapses on the same neuron. The model predicts persisting changes of efficacy in the time-scale of seconds-minutes compatible with short-term memory processes following, in particular, the scheme of classical conditioning.

    Translated title of the contributionMolecular model of the regulation of chemical synapse efficiency at the postsynaptic level
    Original languageFrench
    Pages (from-to)665-670
    Number of pages6
    JournalComptes Rendus de l'Academie des Sciences - Serie III
    Volume295
    Issue number12
    Publication statusPublished - 6 Dec 1982

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