Unmet Needs and Perspectives in Oral Cancer Prevention

Jebrane Bouaoud; Paolo Bossi; Moshe Elkabets; Sandra Schmitz; Léon C. van Kempen; Pierre Martinez; Sankar Jagadeeshan; Ingrid Breuskin; Gerwin J. Puppels; Caroline Hoffmann; Keith D. Hunter; Christian Simon; Jean Pascal Machiels; Vincent Grégoire; Chloé Bertolus; Ruud H. Brakenhoff; Senada Koljenović; Pierre Saintigny

doi:10.3390/cancers14071815

Unmet Needs and Perspectives in Oral Cancer Prevention

Jebrane Bouaoud, Paolo Bossi, Moshe Elkabets, Sandra Schmitz, Léon C. van Kempen, Pierre Martinez, Sankar Jagadeeshan, Ingrid Breuskin, Gerwin J. Puppels, Caroline Hoffmann, Keith D. Hunter, Christian Simon, Jean Pascal Machiels, Vincent Grégoire, Chloé Bertolus, Ruud H. Brakenhoff, Senada Koljenović, Pierre Saintigny

Research output: Contribution to journal › Review article › peer-review

18 Citations (Scopus)

Abstract

Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.

Original language	English
Article number	1815
Journal	Cancers
Volume	14
Issue number	7
DOIs	https://doi.org/10.3390/cancers14071815
Publication status	Published - 1 Apr 2022

Keywords

diagnosis
oral cancer
oral potentially malignant disorders
oral preneoplasia
prevention

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10.3390/cancers14071815

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Bouaoud, J., Bossi, P., Elkabets, M., Schmitz, S., van Kempen, L. C., Martinez, P., Jagadeeshan, S., Breuskin, I., Puppels, G. J., Hoffmann, C., Hunter, K. D., Simon, C., Machiels, J. P., Grégoire, V., Bertolus, C., Brakenhoff, R. H., Koljenović, S., & Saintigny, P. (2022). Unmet Needs and Perspectives in Oral Cancer Prevention. Cancers, 14(7), Article 1815. https://doi.org/10.3390/cancers14071815

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title = "Unmet Needs and Perspectives in Oral Cancer Prevention",

abstract = "Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.",

keywords = "diagnosis, oral cancer, oral potentially malignant disorders, oral preneoplasia, prevention",

author = "Jebrane Bouaoud and Paolo Bossi and Moshe Elkabets and Sandra Schmitz and {van Kempen}, {L{\'e}on C.} and Pierre Martinez and Sankar Jagadeeshan and Ingrid Breuskin and Puppels, {Gerwin J.} and Caroline Hoffmann and Hunter, {Keith D.} and Christian Simon and Machiels, {Jean Pascal} and Vincent Gr{\'e}goire and Chlo{\'e} Bertolus and Brakenhoff, {Ruud H.} and Senada Koljenovi{\'c} and Pierre Saintigny",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = apr,

day = "1",

doi = "10.3390/cancers14071815",

language = "English",

volume = "14",

journal = "Cancers",

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Bouaoud, J, Bossi, P, Elkabets, M, Schmitz, S, van Kempen, LC, Martinez, P, Jagadeeshan, S, Breuskin, I, Puppels, GJ, Hoffmann, C, Hunter, KD, Simon, C, Machiels, JP, Grégoire, V, Bertolus, C, Brakenhoff, RH, Koljenović, S & Saintigny, P 2022, 'Unmet Needs and Perspectives in Oral Cancer Prevention', Cancers, vol. 14, no. 7, 1815. https://doi.org/10.3390/cancers14071815

TY - JOUR

T1 - Unmet Needs and Perspectives in Oral Cancer Prevention

AU - Bouaoud, Jebrane

AU - Bossi, Paolo

AU - Elkabets, Moshe

AU - Schmitz, Sandra

AU - van Kempen, Léon C.

AU - Martinez, Pierre

AU - Jagadeeshan, Sankar

AU - Breuskin, Ingrid

AU - Puppels, Gerwin J.

AU - Hoffmann, Caroline

AU - Hunter, Keith D.

AU - Simon, Christian

AU - Machiels, Jean Pascal

AU - Grégoire, Vincent

AU - Bertolus, Chloé

AU - Brakenhoff, Ruud H.

AU - Koljenović, Senada

AU - Saintigny, Pierre

PY - 2022/4/1

Y1 - 2022/4/1

N2 - Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.

AB - Oral potentially malignant disorders (OPMD) may precede oral squamous cell carcinoma (OSCC). Reported rates of malignant transformation of OPMD range from 3 to 50%. While some clinical, histological, and molecular factors have been associated with a high-risk OPMD, they are, to date, insufficiently accurate for treatment decision-making. Moreover, this range highlights differences in the clinical definition of OPMD, variation in follow-up periods, and molecular and biological heterogeneity of OPMD. Finally, while treatment of OPMD may improve outcome, standard therapy has been shown to be ineffective to prevent OSCC development in patients with OPMD. In this perspective paper, several experts discuss the main challenges in oral cancer prevention, in particular the need to (i) to define an OPMD classification system by integrating new pathological and molecular characteristics, aiming (ii) to better identify OPMD at high risk of malignant transformation, and (iii) to develop treatment strategies to eradicate OPMD or prevent malignant transformation.

KW - diagnosis

KW - oral cancer

KW - oral potentially malignant disorders

KW - oral preneoplasia

KW - prevention

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U2 - 10.3390/cancers14071815

DO - 10.3390/cancers14071815

M3 - Review article

AN - SCOPUS:85127417133

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 7

M1 - 1815

ER -

Unmet Needs and Perspectives in Oral Cancer Prevention

Abstract

Keywords

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