TY - JOUR
T1 - Visual agnosia after treatment of a posterior fossa ependymoma in a 16-month-old girl
AU - Kieffer-Renaux, Virginie
AU - Bulteau, Christine
AU - Grill, Jacques
AU - Levy-Piebois, Christine
AU - Couanet, Dominique
AU - Pierre-Kahn, Alain
AU - Hartmann, Olivier
AU - Kalifa, Chantal
PY - 2001/1/1
Y1 - 2001/1/1
N2 - We present the clinical observation of a 16-month-old girl treated for a posterior fossa ependymoma who experienced severe and delayed visual dysfunction. She was initially treated by surgery and conventional chemotherapy. When she relapsed at age 3 years, the salvage treatment combined high-dose chemotherapy, second surgery, and local irradiation. At age 4 years, disturbed gait and dysarthric speech appeared rapidly, and she became unable to recognize objects and people. Computed tomography revealed bilateral calcifications in the cerebellum and temporal and occipital lobes but no relapse. The neuropsychologic evaluations revealed signs of visual agnosia and marked intellectual impairment. The role of the different treatment modalities in the pathogenesis of this unusual syndrome is discussed.
AB - We present the clinical observation of a 16-month-old girl treated for a posterior fossa ependymoma who experienced severe and delayed visual dysfunction. She was initially treated by surgery and conventional chemotherapy. When she relapsed at age 3 years, the salvage treatment combined high-dose chemotherapy, second surgery, and local irradiation. At age 4 years, disturbed gait and dysarthric speech appeared rapidly, and she became unable to recognize objects and people. Computed tomography revealed bilateral calcifications in the cerebellum and temporal and occipital lobes but no relapse. The neuropsychologic evaluations revealed signs of visual agnosia and marked intellectual impairment. The role of the different treatment modalities in the pathogenesis of this unusual syndrome is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0034770078&partnerID=8YFLogxK
U2 - 10.1177/088307380101600917
DO - 10.1177/088307380101600917
M3 - Article
C2 - 11575616
AN - SCOPUS:0034770078
SN - 0883-0738
VL - 16
SP - 698
EP - 704
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 9
ER -