What role for AID: Mutator, or assembler of the immunoglobulin mutasome?

Claude Agnès Reynaud; Said Aoufouchi; Ahmad Faili; Jean Claude Weill

doi:10.1038/ni0703-631

What role for AID: Mutator, or assembler of the immunoglobulin mutasome?

Claude Agnès Reynaud, Said Aoufouchi, Ahmad Faili, Jean Claude Weill

Research output: Contribution to journal › Review article › peer-review

67 Citations (Scopus)

Abstract

Activation-induced cytidine deaminase (AID) has been shown to trigger three mechanisms for diversifying immunoglobulin genes - somatic hypermutation, isotype switch recombination and gene conversion - most probably by initiating cytidine deamination at the immunoglobulin locus. Although this deamination process has been shown to be potentially mutagenic by itself, most of the mutations generated in the physiological hypermutation process seem to be created through the AID-mediated assembly of a mutasome complex involving specific repair activities and error-prone DNA polymerases.

Original language	English
Pages (from-to)	631-638
Number of pages	8
Journal	Nature Immunology
Volume	4
Issue number	7
DOIs	https://doi.org/10.1038/ni0703-631
Publication status	Published - 1 Jul 2003

Access to Document

10.1038/ni0703-631

Cite this

@article{e354a0bc98db4417997b80b71937c06f,

title = "What role for AID: Mutator, or assembler of the immunoglobulin mutasome?",

abstract = "Activation-induced cytidine deaminase (AID) has been shown to trigger three mechanisms for diversifying immunoglobulin genes - somatic hypermutation, isotype switch recombination and gene conversion - most probably by initiating cytidine deamination at the immunoglobulin locus. Although this deamination process has been shown to be potentially mutagenic by itself, most of the mutations generated in the physiological hypermutation process seem to be created through the AID-mediated assembly of a mutasome complex involving specific repair activities and error-prone DNA polymerases.",

author = "Reynaud, {Claude Agn{\`e}s} and Said Aoufouchi and Ahmad Faili and Weill, {Jean Claude}",

year = "2003",

month = jul,

day = "1",

doi = "10.1038/ni0703-631",

language = "English",

volume = "4",

pages = "631--638",

journal = "Nature Immunology",

issn = "1529-2908",

number = "7",

}

TY - JOUR

T1 - What role for AID

T2 - Mutator, or assembler of the immunoglobulin mutasome?

AU - Reynaud, Claude Agnès

AU - Aoufouchi, Said

AU - Faili, Ahmad

AU - Weill, Jean Claude

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Activation-induced cytidine deaminase (AID) has been shown to trigger three mechanisms for diversifying immunoglobulin genes - somatic hypermutation, isotype switch recombination and gene conversion - most probably by initiating cytidine deamination at the immunoglobulin locus. Although this deamination process has been shown to be potentially mutagenic by itself, most of the mutations generated in the physiological hypermutation process seem to be created through the AID-mediated assembly of a mutasome complex involving specific repair activities and error-prone DNA polymerases.

AB - Activation-induced cytidine deaminase (AID) has been shown to trigger three mechanisms for diversifying immunoglobulin genes - somatic hypermutation, isotype switch recombination and gene conversion - most probably by initiating cytidine deamination at the immunoglobulin locus. Although this deamination process has been shown to be potentially mutagenic by itself, most of the mutations generated in the physiological hypermutation process seem to be created through the AID-mediated assembly of a mutasome complex involving specific repair activities and error-prone DNA polymerases.

UR - http://www.scopus.com/inward/record.url?scp=0037625159&partnerID=8YFLogxK

U2 - 10.1038/ni0703-631

DO - 10.1038/ni0703-631

M3 - Review article

C2 - 12830138

AN - SCOPUS:0037625159

SN - 1529-2908

VL - 4

SP - 631

EP - 638

JO - Nature Immunology

JF - Nature Immunology

IS - 7

ER -

What role for AID: Mutator, or assembler of the immunoglobulin mutasome?

Abstract

Access to Document

Other files and links

Cite this