TY - JOUR
T1 - Whole exome sequencing in molecular diagnostics of cancer decreases over time
T2 - evidence from a cost analysis in the French setting
AU - Bayle, Arnaud
AU - Droin, N.
AU - Besse, B.
AU - Zou, Z.
AU - Boursin, Y.
AU - Rissel, S.
AU - Solary, E.
AU - Lacroix, L.
AU - Rouleau, E.
AU - Borget, I.
AU - Bonastre, J.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/8/1
Y1 - 2021/8/1
N2 - Objectives: Although high-throughput sequencing is revolutionising medicine, data on the actual cost of whole exome sequencing (WES) applications are needed. We aimed at assessing the cost of WES at a French cancer institute in 2015 and 2018. Methods: Actual costs of WES application in oncology research were determined using both micro-costing and gross-costing for the years 2015 and 2018, before and after the acquisition of a new sequencer. The entire workflow process of a WES test was tracked, and the number and unit price of each resource were identified at the most detailed level, from library preparation to bioinformatics analyses. In addition, we conducted an ad hoc analysis of the bioinformatics storage costs of data issued from WES analyses. Results: The cost of WES has decreased substantially, from €1921 per sample (i.e. cost of €3842 per patient) in 2015 to €804 per sample (i.e. cost of €1,608 per patient) in 2018, representing a decrease of 58%. In the meantime, the cost of bioinformatics storage has increased from €19,836 to €200,711. Conclusion: This study suggests that WES cost has decreased significantly in recent years. WES has become affordable, even though clinical utility and efficiency still need to be confirmed.
AB - Objectives: Although high-throughput sequencing is revolutionising medicine, data on the actual cost of whole exome sequencing (WES) applications are needed. We aimed at assessing the cost of WES at a French cancer institute in 2015 and 2018. Methods: Actual costs of WES application in oncology research were determined using both micro-costing and gross-costing for the years 2015 and 2018, before and after the acquisition of a new sequencer. The entire workflow process of a WES test was tracked, and the number and unit price of each resource were identified at the most detailed level, from library preparation to bioinformatics analyses. In addition, we conducted an ad hoc analysis of the bioinformatics storage costs of data issued from WES analyses. Results: The cost of WES has decreased substantially, from €1921 per sample (i.e. cost of €3842 per patient) in 2015 to €804 per sample (i.e. cost of €1,608 per patient) in 2018, representing a decrease of 58%. In the meantime, the cost of bioinformatics storage has increased from €19,836 to €200,711. Conclusion: This study suggests that WES cost has decreased significantly in recent years. WES has become affordable, even though clinical utility and efficiency still need to be confirmed.
KW - Cost analysis
KW - Genomics
KW - Micro-costing
KW - Oncology
KW - Whole exome sequencing
UR - http://www.scopus.com/inward/record.url?scp=85103197092&partnerID=8YFLogxK
U2 - 10.1007/s10198-021-01293-1
DO - 10.1007/s10198-021-01293-1
M3 - Article
C2 - 33765190
AN - SCOPUS:85103197092
SN - 1618-7598
VL - 22
SP - 855
EP - 864
JO - European Journal of Health Economics
JF - European Journal of Health Economics
IS - 6
ER -