Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1

Erika Vacchelli; Yuting Ma; Elisa E. Baracco; Laurence Zitvogel; Guido Kroemer

doi:10.1080/2162402X.2015.1118600

Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1

Erika Vacchelli, Yuting Ma, Elisa E. Baracco, Laurence Zitvogel, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the correct positioning of dendritic cells (DC) close to dying cancer cells. A genetic defect in FPR1 abrogates cross-presentation of tumor antigens by DC, thereby compromising therapy-elicited immunosurveillance.

Original language	English
Article number	e1118600
Journal	OncoImmunology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1080/2162402X.2015.1118600
Publication status	Published - 3 May 2016

Keywords

Annexin A1
Apoptosis
CTL
DAMPs
Immunogenic cell death

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10.1080/2162402X.2015.1118600

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abstract = "Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the correct positioning of dendritic cells (DC) close to dying cancer cells. A genetic defect in FPR1 abrogates cross-presentation of tumor antigens by DC, thereby compromising therapy-elicited immunosurveillance.",

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AU - Zitvogel, Laurence

AU - Kroemer, Guido

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AB - Several pattern recognition receptors including toll-like receptors and purinergic receptors are implicated in the anticancer immune response elicited by anthracyclines or oxaliplatin. Recently, formyl peptide receptor-1 (FPR1) has been involved in this response as well. FPR1 is required for the correct positioning of dendritic cells (DC) close to dying cancer cells. A genetic defect in FPR1 abrogates cross-presentation of tumor antigens by DC, thereby compromising therapy-elicited immunosurveillance.

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KW - CTL

KW - DAMPs

KW - Immunogenic cell death

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Yet another pattern recognition receptor involved in the chemotherapy-induced anticancer immune response: Formyl peptide receptor-1

Abstract

Keywords

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