α-Fetoprotein production by a malignant mixed Mullerian tumor of the ovary

Christine Rebischung; Patricia Pautier; Philippe Morice; Catherine Lhomme; Pierre Duvillard

doi:10.1006/gyno.1999.5653

α-Fetoprotein production by a malignant mixed Mullerian tumor of the ovary

Christine Rebischung, Patricia Pautier, Philippe Morice, Catherine Lhomme, Pierre Duvillard

Résultats de recherche: Contribution à un journal › Article › Revue par des pairs

23 Citations (Scopus)

Résumé

Elevated levels of α-fetoprotein (AFP), a fetal serum protein, usually signal the development of hepatoma or germ cell tumors, including endodermal sinus tumors. We report the case of a 52-year-old woman with an α- fetoprotein-producing malignant mixed Mullerian tumor (MMMT) of the ovary. Serum AFP was 5348 ng/ml at diagnosis. Immunohistochemistry confirmed that the carcinomatous component of this biphasic tumor was the seat of AFP production. After three cycles of combination chemotherapy, the patient achieved a complete remission. Serum AFP was strongly correlated with response to treatment. This is the first report of AFP production by a MMMT of the ovary without a yolk sac component. (C) 2000 Academic Press.

langue originale	Anglais
Pages (de - à)	203-205
Nombre de pages	3
journal	Gynecologic Oncology
Volume	77
Numéro de publication	1
Les DOIs	https://doi.org/10.1006/gyno.1999.5653
état	Publié - 1 janv. 2000

Accès au document

10.1006/gyno.1999.5653

Autres fichiers et liens

Lien vers la publication dans Scopus

Contient cette citation

@article{56279b5b3a6d457c9acf05dcbb8ce839,

title = "α-Fetoprotein production by a malignant mixed Mullerian tumor of the ovary",

abstract = "Elevated levels of α-fetoprotein (AFP), a fetal serum protein, usually signal the development of hepatoma or germ cell tumors, including endodermal sinus tumors. We report the case of a 52-year-old woman with an α- fetoprotein-producing malignant mixed Mullerian tumor (MMMT) of the ovary. Serum AFP was 5348 ng/ml at diagnosis. Immunohistochemistry confirmed that the carcinomatous component of this biphasic tumor was the seat of AFP production. After three cycles of combination chemotherapy, the patient achieved a complete remission. Serum AFP was strongly correlated with response to treatment. This is the first report of AFP production by a MMMT of the ovary without a yolk sac component. (C) 2000 Academic Press.",

keywords = "Malignant mixed Mullerian tumor, Ovarian cancer, α-fetoprotein",

author = "Christine Rebischung and Patricia Pautier and Philippe Morice and Catherine Lhomme and Pierre Duvillard",

year = "2000",

month = jan,

day = "1",

doi = "10.1006/gyno.1999.5653",

language = "English",

volume = "77",

pages = "203--205",

journal = "Gynecologic Oncology",

issn = "0090-8258",

number = "1",

}

TY - JOUR

T1 - α-Fetoprotein production by a malignant mixed Mullerian tumor of the ovary

AU - Rebischung, Christine

AU - Pautier, Patricia

AU - Morice, Philippe

AU - Lhomme, Catherine

AU - Duvillard, Pierre

PY - 2000/1/1

Y1 - 2000/1/1

N2 - Elevated levels of α-fetoprotein (AFP), a fetal serum protein, usually signal the development of hepatoma or germ cell tumors, including endodermal sinus tumors. We report the case of a 52-year-old woman with an α- fetoprotein-producing malignant mixed Mullerian tumor (MMMT) of the ovary. Serum AFP was 5348 ng/ml at diagnosis. Immunohistochemistry confirmed that the carcinomatous component of this biphasic tumor was the seat of AFP production. After three cycles of combination chemotherapy, the patient achieved a complete remission. Serum AFP was strongly correlated with response to treatment. This is the first report of AFP production by a MMMT of the ovary without a yolk sac component. (C) 2000 Academic Press.

AB - Elevated levels of α-fetoprotein (AFP), a fetal serum protein, usually signal the development of hepatoma or germ cell tumors, including endodermal sinus tumors. We report the case of a 52-year-old woman with an α- fetoprotein-producing malignant mixed Mullerian tumor (MMMT) of the ovary. Serum AFP was 5348 ng/ml at diagnosis. Immunohistochemistry confirmed that the carcinomatous component of this biphasic tumor was the seat of AFP production. After three cycles of combination chemotherapy, the patient achieved a complete remission. Serum AFP was strongly correlated with response to treatment. This is the first report of AFP production by a MMMT of the ovary without a yolk sac component. (C) 2000 Academic Press.

KW - Malignant mixed Mullerian tumor

KW - Ovarian cancer

KW - α-fetoprotein

UR - http://www.scopus.com/inward/record.url?scp=0034092674&partnerID=8YFLogxK

U2 - 10.1006/gyno.1999.5653

DO - 10.1006/gyno.1999.5653

M3 - Article

C2 - 10739713

AN - SCOPUS:0034092674

SN - 0090-8258

VL - 77

SP - 203

EP - 205

JO - Gynecologic Oncology

JF - Gynecologic Oncology

IS - 1

ER -