TY - GEN
T1 - 25-Gauge fibered-needle for label-free fluorescence analysis of breast masses
T2 - Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII 2018
AU - Toullec, Alexis
AU - Mathieu, Marie Christine
AU - Benoit, Charlotte
AU - Farcy, René
AU - Tourasse, Christophe
AU - Boisserie-Lacroix, Martine
AU - Fontaine-Aupart, Marie Pierre
AU - Delaloge, Suzette
AU - Balleyguier, Corinne
N1 - Publisher Copyright:
Copyright © 2018 SPIE.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Breast lesions diagnosis and characterization need additional cost-effective techniques to avoid unnecessary invasive procedures, such as core needle biopsies, in the case of benign tumors. Endogenous fluorescence is an effective method to highlight in situ metabolic and/or structural changes between cancerous and non-cancerous lesions. In this context, we developed an original set-up, consisting of a 405 nm laser diode transmitting light through a 25 Gauge (0.45 mm × 50mm) 14° sharp fibered needle to excite intranodular fluorophores around the needle tip and providing real-time labelfree fluorescence spectral analysis of lesions from 450 nm to 650 nm. The objective was to help radiologists to classify suspicious masses in vivo and in real-time within the lesion. We reported the results of spectral differences between 14 invasive lobular carcinomas and 6 intraductal papilloma enrolled in a clinical study.
AB - Breast lesions diagnosis and characterization need additional cost-effective techniques to avoid unnecessary invasive procedures, such as core needle biopsies, in the case of benign tumors. Endogenous fluorescence is an effective method to highlight in situ metabolic and/or structural changes between cancerous and non-cancerous lesions. In this context, we developed an original set-up, consisting of a 405 nm laser diode transmitting light through a 25 Gauge (0.45 mm × 50mm) 14° sharp fibered needle to excite intranodular fluorophores around the needle tip and providing real-time labelfree fluorescence spectral analysis of lesions from 450 nm to 650 nm. The objective was to help radiologists to classify suspicious masses in vivo and in real-time within the lesion. We reported the results of spectral differences between 14 invasive lobular carcinomas and 6 intraductal papilloma enrolled in a clinical study.
UR - http://www.scopus.com/inward/record.url?scp=85046731128&partnerID=8YFLogxK
U2 - 10.1117/12.2286902
DO - 10.1117/12.2286902
M3 - Conference contribution
AN - SCOPUS:85046731128
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII
A2 - Gannot, Israel
A2 - Gannot, Israel
PB - SPIE
Y2 - 27 January 2018 through 28 January 2018
ER -